Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 3 de 3
Acta Trop ; 231: 106437, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-1777304


We assessed the impact of three annual vs five semiannual rounds of mass drug administration (MDA) with ivermectin plus albendazole followed by praziquantel for the control or elimination of lymphatic filariasis (LF), onchocerciasis, soil-transmitted helminth (STH) infections and schistosomiasis in Lofa County, Liberia. The study started in 2012 and was interrupted in 2014 during the Ebola virus outbreak. Repeated cross-sectional surveys were conducted in individuals 5 years and older to measure infection markers. Wuchereria bancrofti antigenemia prevalences decreased from 12.5 to 1.2% (90% reduction) and from 13.6 to 4.2% (69% reduction) one year after three rounds of annual or five rounds of semiannual MDA, respectively. Mixed effects logistic regression models showed decreases in odds of antigenemia positivity were 91 and 74% at that time in the annual and semiannual treatment zones, respectively (p < 0.001). Semiannual MDA was slightly more effective for reducing Onchocerca volvulus microfiladermia prevalence and at follow-up 3 were 74% (from 14.4 to 3.7%) and 83% (from 23.6 to 4.5%) in the annual and semiannual treatment zones, respectively. Both treatment schedules had similar beneficial effects on hookworm prevalence. Thus, annual and semiannual MDA with ivermectin and albendazole had similar beneficial impacts on LF, onchocerciasis, and STH in this setting. In contrast, MDA with praziquantel had little impact on hyperendemic Schistosoma mansoni in the study area. Results from a long-term follow-up survey showed that improvements in infection parameters were sustained by routine annual MDA provided by the Liberian Ministry of Health after our study endpoint.

Elephantiasis, Filarial , Helminthiasis , Onchocerciasis , Albendazole/pharmacology , Albendazole/therapeutic use , Animals , Cross-Sectional Studies , Elephantiasis, Filarial/drug therapy , Elephantiasis, Filarial/epidemiology , Helminthiasis/drug therapy , Helminthiasis/epidemiology , Humans , Ivermectin/pharmacology , Ivermectin/therapeutic use , Liberia/epidemiology , Mass Drug Administration/methods , Onchocerciasis/drug therapy , Onchocerciasis/epidemiology , Praziquantel/pharmacology , Praziquantel/therapeutic use , Prevalence , Soil , Wuchereria bancrofti
Hum Vaccin Immunother ; 17(12): 5150-5152, 2021 Dec 02.
Article in English | MEDLINE | ID: covidwho-1488134


The foremost concerns of COVID-19 vaccines are safety and efficacy, which becomes grave in countries with a high burden of Neglected Tropical Diseases. Studies proposed helminthic infections might alleviate the efficacy of COVID-19 vaccines. We share preliminary evidence on the association between filariasis and COVID-19 infection. We collated 2 ml of blood from 174 participants residing in filariasis endemic area. To determine filarial antigen, the Og4C3 test and for COVID-19 antibodies, tests through ELISA was performed. COVID-19 antibodies were present among 74/174 (42.5%), whereas filarial antigens were detected in 24/174 (13.8%) participants. An insignificant association [OR = 0.855 (0.36-2.034)] between two was observed. Hence, people in filarial endemic regions can continue taking vaccines without worrying about their efficacy due to the helminthic load in community.

COVID-19 , Elephantiasis, Filarial , Animals , Antigens, Helminth/analysis , COVID-19 Vaccines , Elephantiasis, Filarial/epidemiology , Humans , SARS-CoV-2 , Wuchereria bancrofti
PLoS Negl Trop Dis ; 14(11): e0008853, 2020 11.
Article in English | MEDLINE | ID: covidwho-917979


With the evolution of the Coronavirus Disease 2019 (COVID-19) pandemic, the number of patients brought to medical attention has increased. This has led to the unmasking of many coexisting occult infections and comorbidities such as tuberculosis, dengue, human immunodeficiency viral infection, diabetes, and hypertension. We report the first case of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, unveiling the diagnosis of asymptomatic filariasis. A 37-year-old gentleman presented with shortness of breath, fever, and cough. He was found to have COVID-19 pneumonia. During his stay, microfilaria of Wuchereria bancrofti was detected incidentally on a blood smear exam. Consequently, the patient received appropriate treatment for both conditions. In order not to miss relevant concomitant diagnoses, it is prudent to keep a broad differential diagnosis when faced with SARS-CoV-2-infected patients; this is especially true when atypical symptoms are present or in areas endemic with other infections.

Coronavirus Infections/diagnosis , Filariasis/diagnosis , Pneumonia, Viral/diagnosis , Adult , Animals , Betacoronavirus , COVID-19 , Coinfection , Coronavirus Infections/parasitology , Filariasis/virology , Humans , Incidental Findings , Male , Pandemics , Pneumonia, Viral/parasitology , SARS-CoV-2 , Wuchereria bancrofti