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1.
Med Hypotheses ; 143: 109866, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-1386296

ABSTRACT

Zinc Iodide and Dimethyl Sulfoxide compositions are proposed as therapeutic agents to treat and prevent chronic and acute viral infections including SARS-CoV-2 infected patients. The therapeutic combinations have a wide range of virucidal effects on DNA and RNA containing viruses. The combinations also exhibit anti-inflammatory, immunomodulating, antifibrotic, antibacterial, antifungal and antioxidative effects. Given the fact that Zinc Iodide has been used as an oral antiseptic agent and DMSO has been already proven as a safe pharmaceutical solvent and therapeutic agent, we hypothesize that the combination of these two agents can be applied as an effective, safe and inexpensive treatment for SARS-CoV-2 and other viral infection. The therapeutic compound can be applied as both etiological and pathogenesis therapy and used as an effective and safe antiseptic (disinfectant) for human and animals as well.


Subject(s)
Coronavirus Infections/drug therapy , Dimethyl Sulfoxide/administration & dosage , Disinfectants/administration & dosage , Iodides/administration & dosage , Pneumonia, Viral/drug therapy , Zinc Compounds/administration & dosage , Animals , Anti-Inflammatory Agents/administration & dosage , Antioxidants/administration & dosage , Antiviral Agents/administration & dosage , Betacoronavirus , COVID-19 , Drug Therapy, Combination , Humans , Inflammation , Pandemics , SARS-CoV-2 , Solvents , Virus Diseases/drug therapy
2.
Trop Anim Health Prod ; 52(2): 511-515, 2020 Mar.
Article in English | MEDLINE | ID: covidwho-829118

ABSTRACT

The current experiment was performed to find the potential effect of inorganic and organic forms of zinc (Zn) on growth, intestinal histomorphology, immune response, and paraoxonase (PON1) activity in broiler. In this experiment, a total of 450 broiler chickens were assigned to four experimental and control groups. The birds received organic Zn at the rate of 50 mg/kg (OZ-50) and 60 mg/kg (OZ-60) or inorganic Zn at the rate of 50 mg/kg (IZ-50) and 60 mg/kg (IZ-60) for an experimental period of 30 days. Significantly (P < 0.05) higher feed consumption, body weight, feed conversion ratio, and production efficiency factor (PEF) were recorded in OZ-50. Similarly, antibody titer against infectious bronchitis (IB) and PON1 activity was higher (P < 0.05) in OZ-50 compared with the control group. In addition, significantly (P < 0.05) higher villus dimensions and goblet cell count were recorded for the group OZ-50 compared with other treatments. It was concluded that the organic form of Zn was superior in improving the growth, histological features of intestines, humoral response, and PON1 activity in broiler.


Subject(s)
Chickens/growth & development , Chickens/metabolism , Immunity, Innate/drug effects , Intestines/anatomy & histology , Zinc Compounds/metabolism , Zinc/metabolism , Animal Feed/analysis , Animals , Aryldialkylphosphatase/metabolism , Avian Proteins/metabolism , Diet/veterinary , Dietary Supplements/analysis , Dose-Response Relationship, Drug , Intestines/drug effects , Zinc/administration & dosage , Zinc Compounds/administration & dosage
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