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1.
Inflammopharmacology ; 29(4): 1001-1016, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1263162

ABSTRACT

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) known as coronavirus disease (COVID-19), emerged in Wuhan, China, in December 2019. On March 11, 2020, it was declared a global pandemic. As the world grapples with COVID-19 and the paucity of clinically meaningful therapies, attention has been shifted to modalities that may aid in immune system strengthening. Taking into consideration that the COVID-19 infection strongly affects the immune system via multiple inflammatory responses, pharmaceutical companies are working to develop targeted drugs and vaccines against SARS-CoV-2 COVID-19. A balanced nutritional diet may play an essential role in maintaining general wellbeing by controlling chronic infectious diseases. A balanced diet including vitamin A, B, C, D, E, and K, and some micronutrients such as zinc, sodium, potassium, calcium, chloride, and phosphorus may be beneficial in various infectious diseases. This study aimed to discuss and present recent data regarding the role of vitamins and minerals in the treatment of COVID-19. A deficiency of these vitamins and minerals in the plasma concentration may lead to a reduction in the good performance of the immune system, which is one of the constituents that lead to a poor immune state. This is a narrative review concerning the features of the COVID-19 and data related to the usage of vitamins and minerals as preventive measures to decrease the morbidity and mortality rate in patients with COVID-19.


Subject(s)
COVID-19/immunology , COVID-19/prevention & control , Dietary Supplements , Immune System/immunology , Micronutrients/administration & dosage , Minerals/administration & dosage , Vitamins/administration & dosage , Humans , Immune System/drug effects
2.
Future Sci OA ; 6(9): FSO628, 2020 Aug 18.
Article in English | MEDLINE | ID: covidwho-1256152

ABSTRACT

AIM: Low levels of immune-related micronutrients have been identified in ß-thalassemia samples. Moreover, the excess amount of iron, contributing to oxidative stress in the pathogenesis of the disease, alters the immune system in ß-thalassemia, which is important during the COVID-19 pandemic. MATERIALS & METHODS: Searches of PUBMED and EMBASE were conducted to identify the level and supplementation of micronutrients in ß-thalassemia, published from 2001-May 2020. RESULTS: The review found six observational and five interventional studies supporting the importance of supplementing vitamins and minerals among patients with ß-thalassemia. CONCLUSION: Supplementation of immune-related vitamins and minerals might bring benefits to the immune system, especially in reducing oxidative stress in ß-thalassemia.

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