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Int J Clin Pharmacol Ther ; 58(9): 475-481, 2020 Sep.
Artículo en Inglés | MEDLINE | ID: covidwho-690688


AIMS: The aim of this study was to examine the development in the number of patients receiving cardiovascular or antidiabetic medications from pharmacies in the first quarter of 2020. METHODS: This cross-sectional study was based on the data from more than 10 million patients in the IMS longitudinal prescription (LRx) database. The outcome of this study was the development in the number of patients receiving cardiovascular or diabetic medications from pharmacies in January, February, and March 2020, compared to January, February, and March 2019. RESULTS: From March 2019 to March 2020, there was a 39% increase in angiotensin II antagonist prescriptions, a 33% increase in lipid-lowering drug prescriptions, a 32% increase in calcium channel blocker (CCB) prescriptions, a 30% increase in beta blocker prescriptions, a 27% increase in angiotensin-converting enzyme (ACE) inhibitor, vitamin k antagonist (VKA), and oral antidiabetic prescriptions, a 24% increase in diuretic prescriptions, and an 18% increase in insulin prescriptions. The largest increase was found in the age group of 18 - 40 years (e.g., 57% for VKA, 52% for CCB and angiotensin II antagonists), and the smallest increase occurred in the age group over 80 years (for example, 10% for VKA, 9% for oral antidiabetics, and 3% for insulins). CONCLUSION: The number of patients receiving their drugs from pharmacies was significantly higher in March 2020 than in March 2019, which is an indication of good therapy adherence. Additional studies are needed to examine adherence during the COVID-19 pandemic and possible age differences in adherence.

Antihipertensivos/uso terapéutico , Infecciones por Coronavirus/epidemiología , Prescripciones de Medicamentos/estadística & datos numéricos , Hipoglucemiantes/uso terapéutico , Neumonía Viral/epidemiología , Betacoronavirus , Enfermedades Cardiovasculares/prevención & control , Estudios Transversales , Diabetes Mellitus/tratamiento farmacológico , Alemania/epidemiología , Humanos , Pandemias
J Appl Physiol (1985) ; 129(2): 257-262, 2020 08 01.
Artículo en Inglés | MEDLINE | ID: covidwho-670695


The emergence of COVID-19 infection (caused by the SARS-CoV-2 virus) in Wuhan, China in the latter part of 2019 has, within a relatively short time, led to a global pandemic. Amidst the initial spread of SARS-CoV-2 across Asia, an epidemiologic trend emerged in relation to high altitude (HA) populations. Compared with the rest of Asia, SARS-CoV-2 exhibited attenuated rates of expansion with limited COVID-19 infection severity along the Tibetan plateau. These characteristics were soon evident in additional HA regions across Bolivia, central Ecuador, Nepal, Bhutan, and the Sichuan province of mainland China. This mini-review presents a discussion surrounding attributes of the HA environment, aspects of HA physiology, as well as, genetic variations among HA populations which may provide clues for this pattern of SARS-CoV-2 expansion and COVID-19 infection severity. Explanations are provided in the hypothetical, albeit relevant historical evidence is provided to create a foundation for future research.

Altitud , Betacoronavirus , Infecciones por Coronavirus/epidemiología , Pandemias , Neumonía Viral/epidemiología , Bolivia/epidemiología , China/epidemiología , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/metabolismo , Humanos , Nepal/epidemiología , Pandemias/estadística & datos numéricos , Peptidil-Dipeptidasa A/metabolismo , Neumonía Viral/diagnóstico , Neumonía Viral/metabolismo
Circ Arrhythm Electrophysiol ; 13(7): e009007, 2020 07.
Artículo en Inglés | MEDLINE | ID: covidwho-669270
J Adolesc Health ; 67(3): 354-361, 2020 09.
Artículo en Inglés | MEDLINE | ID: covidwho-654937


PURPOSE: The overarching goal of this study was to provide key information on how adolescents' substance use has changed since the corona virus disease (COVID)-19 pandemic, in addition to key contexts and correlates of substance use during social distancing. METHODS: Canadian adolescents (n = 1,054, Mage = 16.68, standard deviation = .78) completed an online survey, in which they reported on their frequency of alcohol use, binge drinking, cannabis use, and vaping in the 3 weeks before and directly after social distancing practices had taken effect. RESULTS: For most substances, the percentage of users decreased; however, the frequency of both alcohol and cannabis use increased. Although the greatest percentage of adolescents was engaging in solitary substance use (49.3%), many were still using substances with peers via technology (31.6%) and, shockingly, even face to face (23.6%). Concerns for how social distancing would affect peer reputation was a significant predictor of face-to-face substance use with friends among adolescents with low self-reported popularity, and a significant predictor of solitary substance use among average and high popularity teens. Finally, adjustment predictors, including depression and fear of the infectivity of COVID-19, predicted using solitary substance use during the pandemic. CONCLUSIONS: Our results provide preliminary evidence that adolescent substance use, including that which occurs face to face with peers, thereby putting adolescents at risk for contracting COVID-19, may be of particular concern during the pandemic. Further, solitary adolescent substance use during the pandemic, which is associated with poorer mental health and coping, may also be a notable concern worthy of further investigation.

Conducta del Adolescente/psicología , Infecciones por Coronavirus/epidemiología , Pandemias , Neumonía Viral/epidemiología , Trastornos Relacionados con Sustancias/epidemiología , Adolescente , Alcoholismo/epidemiología , Canadá/epidemiología , Infecciones por Coronavirus/prevención & control , Femenino , Encuestas Epidemiológicas , Humanos , Masculino , Abuso de Marihuana/epidemiología , Pandemias/prevención & control , Neumonía Viral/prevención & control , Factores de Riesgo , Distancia Social , Vapeo/epidemiología