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SciFinder; 2020.
Preprint | SciFinder | ID: ppcovidwho-5358


The new corona virus (Corona Virus Disease 2019, COVID-19) can enter host cells through angiotensin-converting-enzyme II (ACE2) cell receptors, and previous studies have shown that ACE2 mRNA is normally expressed in digested system cells. The expression of ACE2 protein in normal digestive system, the expression of ACE2 mRNA and its protein in digestive system tumors have not been reported. This article aims to explore the expression of ACE2 in digestive tract and its tumors in order to provide a reference for the prevention and treatment of patients with digestive system tumors. Our results indicate that expression of ACE2 is relatively higher in human digestive system. This result provides some evidence for the transmission of digestivesystem, which may be the infection route of COVID-19. The expression of ACE2 in patients with gastrointestinaltumors is higher than their normal tissues. In order to prevent this possible infection route of the digestive system, the protection of patients with gastrointestinal cancer should be paid great attention.

Chinese Journal of Infectious Diseases ; (12): E006-E006, 2020.
Article Dans Chinois | WPRIM (Pacifique occidental), WPRIM (Pacifique occidental) | ID: covidwho-2054


Objective@#To analysis the clinical characteristics and experiences in diagnosis and treatment of the patients with novel coronavirus pneumonia (NCP).@*Methods@#Clinical data of 28 patients with NCP in Nanning Fourth People's Hospital from January 22 to February 5 in 2020 were collected. The clinical manifestations, epidemiological history, laboratory tests, imaging examinations and treatments of patients were analyzed retrospectively.@*Results@#The 28 patients with confirmed viral pneumonia included 11 males and 17 females, ranging from 11 to 68 years. They all had history of epidemiological exposure and were all positive for 2019-nCoV nucleic acid in throat swabs. There were one mild case, 25 ordinary cases and two severe cases. There were four groups of family clusters. The illness onset ranged from 1 to 12 days after exposure, and the time from the symptom onset to the positive result of the nucleic acid test was 0 to 13 days. The clinical symptoms were mainly fever and cough, which progressed rapidly in a short period of time. Since the onset of illness, the peak values of axillary temperature of the 28 patients were 36.6~39.5 ℃, while five patients had no fever throughout the course of the disease with the peak temperature of ≤37 ℃. There were two patients presented with decreased white blood cell counts, five patients with elevated C reactive protein, six patients with abnormal alanine aminotransferase, three patients with abnormal aspartate aminotransferase,10 patients with elevated creatine kinase, three patients with elevated creatine kinase isoenzyme, four patients with elevated lactate dehydrogenase, and all with normal procalcitonin levels. The chest computed tomography examinations showed that the common features were ground glass shadows (21 cases), blurred edges (18 cases), speckles and patchy shadows (17 cases), thickening and disorder of some lung textures (7 cases), and visible band shadows (7 cases). Pulmonary lesions often progressed rapidly. One 11-year-old child was treated with alpha-interferon alone, and 27 patients were treated with alpha-interferon inhalation plus lopinavir/ritonavir with 4 withdrawal due to adverse reactions. Up to February 12, nine patients had been discharged from the hospital, who were ordinary cases, without death cases.@*Conclusions@#The NCP patients mostly present with fever and cough. Pulmonary lesions often progress rapidly. Respiratory pathogen testing should be conducted as early as possible and repeatedly. Disisolation should be cautious for suspected people who are negative for 2019-nCoV nucleic acid in pharynx swabs.

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