Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 41.120
Filtrar
Adicionar filtros

Ano de publicação
Intervalo de ano
1.
Wounds UK ; 16(2):10, 2020.
Artigo | COVIDWHO | ID: covidwho-629049
2.
Sugar Industry-Zuckerindustrie ; 145(5):267-269, 2020.
Artigo | COVIDWHO | ID: covidwho-629043
3.
Deutsche Apotheker Zeitung ; 60(18), 2020.
Artigo | COVIDWHO | ID: covidwho-629032
4.
New Scientist ; 246(3288):11, 2020.
Artigo | COVIDWHO | ID: covidwho-629019

RESUMO

The doctor who devised New Zealand's early and extensive coronavirus response tells Alice Klein what inspired his successful strategy

5.
International Journal of Drug Policy ; 2020.
Artigo | COVIDWHO | ID: covidwho-629018
6.
Infectious Disease Modelling ; 2020.
Artigo | COVIDWHO | ID: covidwho-629014

RESUMO

As every country in the world struggles with the ongoing COVID-19 pandemic, it is essential that as many people as possible understand the epidemic containment, elimination and exclusion strategies required to tackle it Simplified arithmetic models of COVID-19 transmission, control and elimination are presented in user-friendly Shiny and Excel formats that allow non-specialists to explore, query, critique and understand the containment decisions facing their country and the world at large Although the predictive model is broadly applicable, the simulations presented are based on parameter values representative of the United Republic of Tanzania, which is still early enough in its epidemic cycle and response to avert a national catastrophe The predictions of these models illustrate (1) why ambitious lock-down interventions to crush the curve represent the only realistic way for individual countries to contain their national-level epidemics before they turn into outright catastrophes, (2) why these need to be implemented so early, so stringently and for such extended periods, (3) why high prevalence of other pathogens causing similar symptoms to mild COVID-19 precludes the use of contact tracing as a substitute for lock down interventions to contain and eliminate epidemics, (4) why partial containment strategies intended to merely flatten the curve, by maintaining epidemics at manageably low levels, are grossly unrealistic, and (5) why local elimination may only be sustained after lock down ends if imported cases are comprehensively excluded, so international co-operation to conditionally re-open trade and travel between countries certified as free of COVID-19 represents the best strategy for motivating progress towards pandemic eradication at global level The three sequential goals that every country needs to emphatically embrace are contain, eliminate and exclude As recently emphasized by the World Health Organization, success will require widespread genuine national unity and unprecedented global solidarity

7.
New Journal of Chemistry ; 44(22):9202-9212, 2020.
Artigo | COVIDWHO | ID: covidwho-629008

RESUMO

Viruses belonging to the family Coronaviridae consist of virulent pathogens that have a zoonotic property Severe acute respiratory syndrome coronaviruses (SARS-CoVs) and Middle East respiratory syndrome coronaviruses (MERS-CoVs) of this family have emerged before and SARS-CoV-2 has emerged now globally The characterization of spike glycoproteins, polyproteins and other viral proteins from viruses is important for antiviral drug development Homology modelling of these proteins with known templates offers the opportunity to discover ligand-binding sites and explore the possible antiviral properties of these protein-ligand complexes In this study, we performed a complete bioinformatic analysis, sequence alignment, comparison of multiple sequences and modelling of the SARS-CoV-2 whole-genome sequences, the spike protein and the polyproteins for homology with known proteins We also analysed binding sites in these models for possible binding with ligands that exhibit antiviral properties Our results indicated that the sequence of the polyprotein isolate SARS-CoV-2_HKU-SZ-001_2020 showed 98 94 percent identity to SARS-coronavirus NSP12 bound to NSP7 and NSP8 co-factors The results also indicated that a part of the viral genome (residues 3268-3573 in Frame 2 with 306 amino acids) of the SARS-CoV-2 isolate Wuhan-Hu-1 (GenBank Accession Number MN908947 3) when modelled with templateof the PDB database showed 96 percent identity to a 3C-like peptidase of SARS-CoVs, which has the ability to bind with an aza-peptide epoxide (APE) known for the irreversible inhibition of SARS-CoV main peptidase A docking profile with 9 different conformations of the ligand with the protein model using Autodock Vina showed an affinity of −7 1 kcal mol−1 This region was conserved in 831 genomes of SARS-CoV-2 The part of the genome (residues 1568-1882 in Frame 2 with 315 amino acids) when modelled with template of the PDB database showed 82 percent identity to a papain-like protease/deubiquitinase, which when complexed with ligand GRL0617 acts as an inhibitor and can block SARS-CoV replication A docking profile with 9 different conformations of the ligand with the protein model using Autodock Vina showed an affinity of −7 9 kcal mol−1 This region was conserved in 831 genomes of SARS-CoV-2 It is possible that these ligands can be used as antivirals of SARS-CoV-2

8.
Nordic Studies on Alcohol and Drugs ; 37(3):205-207, 2020.
Artigo | COVIDWHO | ID: covidwho-629006
9.
Med ; 2020.
Artigo | COVIDWHO | ID: covidwho-628996

RESUMO

A growing body of evidence indicates that obesity is strongly and independently associated with adverse outcomes of COVID-19 including death By combining emerging knowledge of the pathological processes involved in COVID-19 with insights into the mechanisms underlying the adverse health consequences of obesity, we present some hypotheses regarding the deleterious impact of obesity on the course of COVID-19 These hypotheses are testable and could guide therapeutic and preventive interventions As obesity is now almost ubiquitous and no vaccine for COVID-19 is currently available, even a modest reduction in the impact of obesity on mortality and morbidity from this viral infection could have profound consequences for public health

10.
EClinicalMedicine ; 24:100423, 2020.
Artigo | COVIDWHO | ID: covidwho-628989
11.
Energy Research & Social Science ; 68:101666, 2020.
Artigo | COVIDWHO | ID: covidwho-628976

RESUMO

The COVID-19 pandemic is a major landscape shock that is having pervasive effects across socio-technical systems Due to its recentness, sustainability scientists and other researchers have only started to investigate the implications of this crisis The COVID-19 outbreak presents a unique opportunity to analyze in real time the effects of a protracted landscape-scale perturbation on the trajectories of sustainability transitions In this perspective, we explore the ramifications for sustainability transition research on electricity and mobility, drawing from selected examples in Finland and Sweden The long-term consequences of the COVID-19 pandemic are likely to trigger more permanent changes connected to the digitalization of work and other daily activities, thus reducing mobility needs and overall fossil-energy consumption The crisis may encourage governance systems to be better prepared for different types of shocks in the future, while it also contains a threat of increasingly populist or undemocratic political responses and increased securitization These developments can guide research by addressing the reproduction of new practices arising from the COVID-19 outbreak to accelerate sustainability transitions, enhancing understanding of the role of governance in transitions, and bringing to attention the ethical and political implications of landscape shocks

12.
American Journal of Infection Control ; 2020.
Artigo | COVIDWHO | ID: covidwho-628971
13.
Dialog ; n/a(n/a), 2020.
Artigo | COVIDWHO | ID: covidwho-628969

RESUMO

Abstract The Covid-19 pandemic is exposing how humans have long related to nature, and revealing aspects of classism and racism that have long been ignored Drawing on spiritual resources, such as Luther, might the polarizing, self versus other tendencies be overcome and the long pandemic rooted in economic class and racism more effectively addressed today? Can this result in a ?new normal??

15.
JACC: Basic to Translational Science ; 2020.
Artigo | COVIDWHO | ID: covidwho-628932
17.
Journal of Environmental Psychology ; 2020.
Artigo | COVIDWHO | ID: covidwho-628832

RESUMO

The COVID-19 pandemic has understandably dominated public discourse, crowding out other important issues such as climate change Currently, if climate change enters the arena of public debate, it primarily does so in direct relation to the pandemic In two experiments, we investigated (1) whether portraying the response to the COVID-19 threat as a “trial run” for future climate action would increase climate-change concern and mitigation support, and (2) whether portraying climate change as a concern that needs to take a “back seat” while focus lies on economic recovery would decrease climate-change concern and mitigation support We found no support for the effectiveness of a trial-run frame in either experiment In Experiment 1, we found that a back-seat frame reduced participants’ support for mitigative action In Experiment 2, the back-seat framing reduced both climate-change concern and mitigation support;a combined inoculation and refutation was able to offset the drop in climate concern but not the reduction in mitigation support

19.
Public Health ; 2020.
Artigo | COVIDWHO | ID: covidwho-628812

RESUMO

ABSTRACT Introduction As part of the COVID-19 outbreak response, numerous technology-based solutions have been created to enable contact tracing, track movements of the population and ensure social control Wearable biometric bracelets are widespread and commonly used in the form of wrist-worn activity trackers that are both familiar and liked by the general population Objectives/Study Design/Methods The authors propose an innovative approach - a wearable bracelet that can be used to curb the spread of Covid-19 The bracelet would facilitate 3 functions;screening on a population level, digital contact tracing and real-time immunity status tracking Results/Conclusions Utilising the Internet of Things, data would then be transfer over a network to interactive web-based dashboard and big data analytics employed to augment response within a defined geographic region

20.
Journal of Pharmaceutical Analysis ; 2020.
Artigo | COVIDWHO | ID: covidwho-628810

RESUMO

COVID-19, a disease caused by the novel coronavirus SARS-CoV-2, has produced a serious emergency for global public health, placing enormous stress on national health systems in many countries Several studies suggest that cytokine storms (interleukins) may play an important role in severe cases of COVID-19 Neutralizing key inflammatory factors in cytokine release syndrome (CRS) could therefore be of great value in reducing the mortality rate Tocilizumab (TCZ) in its intravenous (IV) form of administration -RoActemra® 20 mg/mL (Roche)- is indicated for treatment of severe CRS patients Preliminary investigations have concluded that inhibition of IL-6 with TCZ appears to be efficacious and safe, with several ongoing clinical trials This has led to a huge increase in demand for IV TCZ for treating severe COVID-19 patients in hospitals, which has resulted in shortages Here, we present a comparability study assessing the main critical physicochemical attributes of TCZ solutions used for infusion, at 6 mg/mL and 4 mg/mL, prepared from RoActeram® 20 mg/mL (IV form) and from RoActemra® 162 mg (0 9 mL solution pre-filled syringe, subcutaneous form), to evaluate the use of the latter for preparing clinical solutions required for IV administration, so that in a situation of shortage of the IV medicine, the SC form could be used to prepare the solutions for IV delivery of TCZ It is important to remember that during the current pandemic all the medicines are used off-label, since none of them has yet been approved for the treatment of COVID-19

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA