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BNT162b2 and mRNA-1273 COVID-19 vaccine effectiveness against the Delta (B.1.617.2) variant in Qatar (preprint)
medrxiv; 2021.
ما قبل الطباعة
ي الانجليزية
| medRxiv | ID: ppzbmed-10.1101.2021.08.11.21261885
ABSTRACT
The SARS-CoV-2 Delta (B.1.617.2) variant of concern is expanding globally. Here, we assess real-world effectiveness of the BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) vaccines against this variant in the population of Qatar, using a matched test-negative, case- control study design. BNT162b2 effectiveness against any Delta infection, symptomatic or asymptomatic, was 64.2% (95% CI 38.1-80.1%) [≥]14 days after the first dose and before the second dose, but was only 53.5% (95% CI 43.9-61.4%) [≥]14 days after the second dose, in a population in which a large proportion of fully vaccinated persons received their second dose several months earlier. Corresponding effectiveness measures for mRNA-1273 were 79.0% (95% CI 58.9-90.1%) and 84.8% (95% CI 75.9-90.8%), respectively. Effectiveness against any severe, critical, or fatal COVID-19 disease due to Delta was 89.7% (95% CI 61.0-98.1%) for BNT162b2 and 100.0% (95% CI 41.2-100.0%) for mRNA-1273, [≥]14 days after the second dose. Both BNT162b2 and mRNA-1273 are highly effective in preventing Delta hospitalization and death, but less so in preventing infection, particularly for BNT162b2.
النص الكامل:
متاح
مجموعة:
المطبوعات المسبقة
قاعدة البيانات:
medRxiv
الموضوع الرئيسي:
Hepatitis D
/
Death
/
COVID-19
اللغة:
الانجليزية
السنة:
2021
نوع:
ما قبل الطباعة
المراجع ذات الصلة
MEDLINE
...
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