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Bee Venom-A Potential Complementary Medicine Candidate for SARS-CoV-2 Infections.
Kasozi, Keneth Iceland; Niedbala, Gniewko; Alqarni, Mohammed; Zirintunda, Gerald; Ssempijja, Fred; Musinguzi, Simon Peter; Usman, Ibe Michael; Matama, Kevin; Hetta, Helal F; Mbiydzenyuy, Ngala Elvis; Batiha, Gaber El-Saber; Beshbishy, Amany Magdy; Welburn, Susan Christina.
  • Kasozi KI; Infection Medicine, Deanery of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom.
  • Niedbala G; School of Medicine, Kabale University, Kabale, Uganda.
  • Alqarni M; Department of Biosystems Engineering, Faculty of Environmental Engineering and Mechanical Engineering, Poznan University of Life Sciences, Poznan, Poland.
  • Zirintunda G; Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif, Saudi Arabia.
  • Ssempijja F; Faculty of Agriculture and Animal Sciences, Busitema University Arapai Campus, Soroti, Uganda.
  • Musinguzi SP; Faculty of Biomedical Sciences, Kampala International University Western Campus, Bushenyi, Uganda.
  • Usman IM; School of Medicine, Kabale University, Kabale, Uganda.
  • Matama K; Faculty of Biomedical Sciences, Kampala International University Western Campus, Bushenyi, Uganda.
  • Hetta HF; Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy, Kampala International University Western Campus, Bushenyi, Uganda.
  • Mbiydzenyuy NE; Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Batiha GE; Department of Basic Medical Sciences, Michael Chilufya Sata School of Medicine, Copperbelt University, Ndola, Zambia.
  • Beshbishy AM; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.
  • Welburn SC; National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Front Public Health ; 8: 594458, 2020.
Article in English | MEDLINE | ID: covidwho-1000215
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by severe cytokine storm syndrome following inflammation. SARS-CoV-2 directly interacts with angiotensin-converting enzyme 2 (ACE-2) receptors in the human body. Complementary therapies that impact on expression of IgE and IgG antibodies, including administration of bee venom (BV), have efficacy in the management of arthritis, and Parkinson's disease. A recent epidemiological study in China showed that local beekeepers have a level of immunity against SARS-CoV-2 with and without previous exposure to virus. BV anti-inflammatory properties are associated with melittin and phospholipase A2 (PLA2), both of which show activity against enveloped and non-enveloped viruses, including H1N1 and HIV, with activity mediated through antagonist activity against interleukin-6 (IL-6), IL-8, interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α). Melittin is associated with the underexpression of proinflammatory cytokines, including nuclear factor-kappa B (NF-κB), extracellular signal-regulated kinases (ERK1/2), and protein kinase Akt. BV therapy also involves group III secretory phospholipase A2 in the management of respiratory and neurological diseases. BV activation of the cellular and humoral immune systems should be explored for the application of complementary medicine for the management of SARS-CoV-2 infections. BV "vaccination" is used to immunize against cytomegalovirus and can suppress metastases through the PLA2 and phosphatidylinositol-(3,4)-bisphosphate pathways. That BV shows efficacy for HIV and H1NI offers opportunity as a candidate for complementary therapy for protection against SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Bee Venoms / Complementary Therapies / Cytokines / COVID-19 Type of study: Observational study Topics: Traditional medicine / Vaccines Limits: Humans / Male Country/Region as subject: Asia Language: English Journal: Front Public Health Year: 2020 Document Type: Article Affiliation country: Fpubh.2020.594458

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Bee Venoms / Complementary Therapies / Cytokines / COVID-19 Type of study: Observational study Topics: Traditional medicine / Vaccines Limits: Humans / Male Country/Region as subject: Asia Language: English Journal: Front Public Health Year: 2020 Document Type: Article Affiliation country: Fpubh.2020.594458