Convalescent plasma for COVID-19: Promising, not proven.

Mucha, Simon R; Quraishy, NurJehan

Mucha, Simon R; Quraishy, NurJehan.

Mucha SR; Department of Critical Care Medicine, Respiratory Institute, Cleveland Clinic; Clinical Instructor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
Quraishy N; Section Head Transfusion Medicine, Department of Clinical Pathology, Cleveland Clinic; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH quraisn@ccf.org.

Cleve Clin J Med ; 87(11): 664-670, 2020 11 02.

Article in English | MEDLINE | ID: covidwho-1000386

ABSTRACT

ABSTRACT

While promising, convalescent plasma remains experimental and is not proven effective for COVID-19. In addition, many questions remain regarding the accuracy and predictive value of antibody testing of donors and patients, optimal donor selection, optimal timing, and selection of patients most likely to benefit. Until these questions are answered, convalescent plasma should ideally be used in the context of well-designed clinical trials.

Subject(s)

Betacoronavirus; Clinical Laboratory Techniques/methods; Coronavirus Infections; Pandemics; Pneumonia, Viral; Time-to-Treatment; Betacoronavirus/immunology; Betacoronavirus/isolation & purification; COVID-19; COVID-19 Testing; Clinical Trials as Topic; Coronavirus Infections/diagnosis; Coronavirus Infections/genetics; Coronavirus Infections/immunology; Coronavirus Infections/therapy; Donor Selection; Humans; Immunization, Passive/adverse effects; Immunization, Passive/methods; Patient Selection; Pneumonia, Viral/diagnosis; Pneumonia, Viral/genetics; Pneumonia, Viral/immunology; Pneumonia, Viral/therapy; Predictive Value of Tests; Reproducibility of Results; Risk Assessment; SARS-CoV-2; Treatment Outcome; COVID-19 Serotherapy

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Clinical Laboratory Techniques / Pandemics / Time-to-Treatment / Betacoronavirus Type of study: Diagnostic study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Cleve Clin J Med Journal subject: Medicine Year: 2020 Document Type: Article

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