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Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19.
Omarjee, Loukman; Perrot, Frédérique; Meilhac, Olivier; Mahe, Guillaume; Bousquet, Guilhem; Janin, Anne.
  • Omarjee L; Vascular Medicine Department, CHU Rennes, French National Health and Medical Research (Inserm), Clinical Investigation Center (CIC) 1414, University of Rennes 1, Rennes F-35033, France.
  • Perrot F; NuMeCan Institute, Exogenous and Endogenous Stress and Pathological Responses in Hepato-Gastrointestinal Diseases (EXPRES) Team, French National Health and Medical Research (Inserm) U1241, University of Rennes 1, Rennes F-35033, France.
  • Meilhac O; Cellular and Molecular Biology Consultant, Rennes F-35033, France.
  • Mahe G; University of Reunion Island, INSERM, UMR 1188 Reunion, Indian Ocean Diabetic Atherothrombosis Therapies (DéTROI), CHU de La Réunion, Saint-Denis de La Réunion F-97400, France.
  • Bousquet G; Vascular Medicine Department, CHU Rennes, French National Health and Medical Research (Inserm), Clinical Investigation Center (CIC) 1414, University of Rennes 1, Rennes F-35033, France.
  • Janin A; AP-HP Hôpital Avicenne, Oncologie Médicale, Bobigny F-93000, France.
Aging (Albany NY) ; 12(24): 26263-26278, 2020 12 27.
Article in English | MEDLINE | ID: covidwho-1000742
ABSTRACT
Inflammaging constitutes the common factor for comorbidities predisposing to severe COVID-19. Inflammaging leads to T-cell senescence, and immunosenescence is linked to autoimmune manifestations in COVID-19. As in SLE, metabolic dysregulation occurs in T-cells. Targeting this T-cell dysfunction opens the field for new therapeutic strategies to prevent severe COVID-19. Immunometabolism-mediated approaches such as rapamycin, metformin and dimethyl fumarate, may optimize COVID-19 treatment of the elderly and patients at risk for severe disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmunity / Energy Metabolism / Host-Pathogen Interactions / Immunosenescence / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Aging (Albany NY) Journal subject: Geriatrics Year: 2020 Document Type: Article Affiliation country: Aging.202422

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmunity / Energy Metabolism / Host-Pathogen Interactions / Immunosenescence / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Aging (Albany NY) Journal subject: Geriatrics Year: 2020 Document Type: Article Affiliation country: Aging.202422