Biomarker profile in pediatric inflammatory multisystem syndrome temporarily associated with SARS-CoV-2 (PIMS-TS)/multisystem inflammatory syndrome in children (MIS-C)
Indian Journal of Biochemistry & Biophysics
; 57(6):687-693, 2020.
Article
in English
| Web of Science | ID: covidwho-1001038
ABSTRACT
Pediatric Inflammatory Multisystem Syndrome temporarily associated with SARS-CoV-2 (P1MS-TS) or Multisystem Inflammatory Syndrome in Children (MIS-C) is a post COVID-19 multisystem inflammatory syndrome in children and adolescents <21 years of age. It is slowly emerging in India with clinical features overlapping with Kawasaki Disease (KD) and Toxic Shock Syndrome (TSS). Ten P1MS-TS cases admitted in a pediatric hospital between July and Sept 2020 were compared with 19 Kawasaki Disease (KD) patients' data. The median age of PIMS-TS was 6 years (older to KD), 80% were males. PMS-TS cases had high inflammatory markers CRP, ferritin, interleukin (IL)-6. Other distinct features were lymphopenia, hypoalbuminemia, and hyponatremia. Serial measurements of CRP showed high baseline values with subsequent decrease. NT-Pro BNP level was extremely elevated;suggestive of cardiac injury. All patients recovered. Laboratory features of P1MS-TS present a unique pattern of intense inflammation, and cardiac involvement that is different from features of pre COVID-19 KD. CRP remains a useful, inexpensive marker for P1MS-TS diagnosis and clinical progression.
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Collection:
Databases of international organizations
Database:
Web of Science
Language:
English
Journal:
Indian Journal of Biochemistry & Biophysics
Year:
2020
Document Type:
Article
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