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Vitamin D and its therapeutic relevance in pulmonary diseases.
Ahmad, Shaniya; Arora, Shweta; Khan, Salman; Mohsin, Mohd; Mohan, Anant; Manda, Kailash; Syed, Mansoor Ali.
  • Ahmad S; Translational Research Lab, Department of Biotechnology, Jamia Millia Islamia, New Delhi, India; Institute of Nuclear Medicine and Allied Science, Defence Research and Development Organisation, New Delhi, India.
  • Arora S; Translational Research Lab, Department of Biotechnology, Jamia Millia Islamia, New Delhi, India.
  • Khan S; Translational Research Lab, Department of Biotechnology, Jamia Millia Islamia, New Delhi, India.
  • Mohsin M; Translational Research Lab, Department of Biotechnology, Jamia Millia Islamia, New Delhi, India.
  • Mohan A; Department of Pulmonary Medicine, AIIMS, New Delhi, India.
  • Manda K; Institute of Nuclear Medicine and Allied Science, Defence Research and Development Organisation, New Delhi, India.
  • Syed MA; Translational Research Lab, Department of Biotechnology, Jamia Millia Islamia, New Delhi, India. Electronic address: smansoor@jmi.ac.in.
J Nutr Biochem ; 90: 108571, 2021 04.
Article in English | MEDLINE | ID: covidwho-1001603
ABSTRACT
Vitamin D is customarily involved in maintaining bone and calcium homeostasis. However, contemporary studies have identified the implication of vitamin D in several cellular processes including cellular proliferation, differentiation, wound healing, repair and regulatory systems inclusive of host defence, immunity, and inflammation. Multiple studies have indicated corelations between low serum levels of vitamin D, perturbed pulmonary functions and enhanced incidences of inflammatory diseases. Almost all of the pulmonary diseases including acute lung injury, cystic fibrosis, asthma, COPD, Pneumonia and Tuberculosis, all are inflammatory in nature. Studies have displayed strong inter-relations with vitamin D deficiency and progression of lung disorders; however, the underlying mechanism is still unknown. Vitamin D has emerged to possess inhibiting effects on pulmonary inflammation while exaggerating innate immune defenses by strongly influencing functions of inflammatory cells including dendritic cells, monocyte/macrophages, T cells, and B cells along with structural epithelial cells. This review dissects the effects of vitamin D on the inflammatory cells and their therapeutic relevance in pulmonary diseases. Although, the data obtained is very limited and needs further corroboration but presents an exciting area of further research. This is because of its ease of supplementation and development of personalized medicine which could lead us to an effective adjunct and cost-effective method of therapeutic modality for highly fatal pulmonary diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Diseases / Vitamin D / Vitamin D Deficiency Type of study: Observational study Limits: Animals / Humans Language: English Journal: J Nutr Biochem Journal subject: Biochemistry / Nutritional Sciences Year: 2021 Document Type: Article Affiliation country: J.jnutbio.2020.108571

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Diseases / Vitamin D / Vitamin D Deficiency Type of study: Observational study Limits: Animals / Humans Language: English Journal: J Nutr Biochem Journal subject: Biochemistry / Nutritional Sciences Year: 2021 Document Type: Article Affiliation country: J.jnutbio.2020.108571