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ADAMTS proteases and the tumor immune microenvironment: Lessons from substrates and pathologies.
Redondo-García, Silvia; Peris-Torres, Carlos; Caracuel-Peramos, Rita; Rodríguez-Manzaneque, Juan Carlos.
  • Redondo-García S; GENYO, Centre for Genomics and Oncological Research, Pfizer/Universidad de Granada/Junta de Andalucía, Avenida de la Ilustración, 114, Granada 18016, Spain.
  • Peris-Torres C; GENYO, Centre for Genomics and Oncological Research, Pfizer/Universidad de Granada/Junta de Andalucía, Avenida de la Ilustración, 114, Granada 18016, Spain.
  • Caracuel-Peramos R; GENYO, Centre for Genomics and Oncological Research, Pfizer/Universidad de Granada/Junta de Andalucía, Avenida de la Ilustración, 114, Granada 18016, Spain.
  • Rodríguez-Manzaneque JC; GENYO, Centre for Genomics and Oncological Research, Pfizer/Universidad de Granada/Junta de Andalucía, Avenida de la Ilustración, 114, Granada 18016, Spain.
Matrix Biol Plus ; 9: 100054, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1001624
ABSTRACT
The relationship of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteases with inflammatory processes was anticipated since their discovery. Although knowledge of these extracellular proteases in different contexts continues to grow, many questions remain unanswered. In this review, we summarize the most important studies of ADAMTSs and their substrates in inflammation and in the immune system of non-oncological disorders. In addition, we update the findings on cancer and highlight their emerging role in the tumor immune microenvironment. Although the overall functions of extracellular molecules are known to be modulated by proteolysis, specific activities attributed to intact proteins and cleaved fragments in the context of inflammation are still subject to debate. A better understanding of ADAMTS activities will help to elucidate their contribution to the immune phenotype and to open up new therapeutic and diagnostic possibilities.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Matrix Biol Plus Year: 2021 Document Type: Article Affiliation country: J.mbplus.2020.100054

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Matrix Biol Plus Year: 2021 Document Type: Article Affiliation country: J.mbplus.2020.100054