SARS-CoV-2 nucleocapsid protein intranasal inoculation induces local and systemic T cell responses in mice.
J Med Virol
; 93(4): 1923-1925, 2021 04.
Article
in English
| MEDLINE | ID: covidwho-1001944
ABSTRACT
SARS-CoV-2 nucleocapsid (N) protein has been proposed as a good vaccine target. N-specific T cells were observed in SARS-CoV-2 N immunized mice and COVID-19 convalescents. It is of importance to identify the T cell responses triggered by SARS-CoV-2 N protein. Intradermal immunization with SARS-CoV N protein was demonstrated to elicit non-protective T cell responses which may be avoided by intranasal vaccination. Therefore, we conducted intranasal vaccination of BALB/c mice with recombinant adenovirus type-5 expressing SARS-CoV-2 N protein. Such procedure induced CD8 T cell responses in the lung. Meanwhile CD4 T cell responses were observed in the spleen, which was associated with robust antibody production. Our study further supports the notion that SARS-CoV-2 N protein can work as a target for vaccine development.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Viral Vaccines
/
T-Lymphocytes
/
Coronavirus Nucleocapsid Proteins
/
COVID-19
/
Antibodies, Viral
Topics:
Vaccines
Limits:
Animals
Language:
English
Journal:
J Med Virol
Year:
2021
Document Type:
Article
Affiliation country:
Jmv.26769
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