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Therapeutic targets and potential agents for the treatment of COVID-19.
Wu, Yinuo; Li, Zhe; Zhao, Yun-Song; Huang, Yi-You; Jiang, Mei-Yan; Luo, Hai-Bin.
  • Wu Y; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
  • Li Z; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
  • Zhao YS; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
  • Huang YY; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
  • Jiang MY; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
  • Luo HB; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
Med Res Rev ; 41(3): 1775-1797, 2021 05.
Article in English | MEDLINE | ID: covidwho-1001951
ABSTRACT
The outbreak of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has become a global crisis. As of November 9, COVID-19 has already spread to more than 190 countries with 50,000,000 infections and 1,250,000 deaths. Effective therapeutics and drugs are in high demand. The structure of SARS-CoV-2 is highly conserved with those of SARS-CoV and Middle East respiratory syndrome-CoV. Enzymes, including RdRp, Mpro /3CLpro , and PLpro , which play important roles in viral transcription and replication, have been regarded as key targets for therapies against coronaviruses, including SARS-CoV-2. The identification of readily available drugs for repositioning in COVID-19 therapy is a relatively rapid approach for clinical treatment, and a series of approved or candidate drugs have been proven to be efficient against COVID-19 in preclinical or clinical studies. This review summarizes recent progress in the development of drugs against SARS-CoV-2 and the targets involved.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Journal: Med Res Rev Year: 2021 Document Type: Article Affiliation country: Med.21776

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Journal: Med Res Rev Year: 2021 Document Type: Article Affiliation country: Med.21776