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The impact and prevalence of SARS-CoV-2 in patients with head and neck cancer and acute upper airway infection in a tertiary otorhinolaryngology referral center in Denmark.
Andersen, Peter Anders; Rasmussen, Kasper Møller Boje; Channir, Hani Ibrahim; von Buchwald, Christian; Cayé-Thomasen, Per; Klokker, Mads; Knudsen, Jenny Dahl; Kirkby, Nikolai Søren; Aanaes, Kasper; Jensen, Ramon Gordon.
  • Andersen PA; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark. andersenpetera@gmail.com.
  • Rasmussen KMB; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.
  • Channir HI; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.
  • von Buchwald C; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.
  • Cayé-Thomasen P; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Klokker M; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.
  • Knudsen JD; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Kirkby NS; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.
  • Aanaes K; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Jensen RG; Department of Clinical Microbiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Eur Arch Otorhinolaryngol ; 278(9): 3409-3415, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1002084
ABSTRACT

PURPOSE:

To determine the prevalence of SARS-CoV-2 at a Danish tertiary referral otorhinolaryngology clinic during the first wave of the COVID-19 pandemic among patients with suspected acute upper airway infection (UAI) and patients operated for head and neck cancer (HNC), respectively. To monitor changes in the number of patient encounters for acute UAI and the number of referrals for the workup of HNC. TRIAL REGISTRATION NCT-04356560 (Clinicaltrials.gov).

METHODS:

Prospective enrolled case series of all patients with suspected acute UAI (n = 88) and of patients undergoing surgery for HNC (n = 96), respectively, from March 23rd to May 5th, 2020, at a public tertiary referral otorhinolaryngology clinic in Denmark. SARS-CoV-2 was diagnosed with nasopharyngeal and oropharyngeal swabbing. Patients with suspected acute UAI had symptoms and definitive diagnoses registered in a database. Trends in the number of referrals and patient encounters were retrieved from an electronic patient journal system and analyzed retrospectively.

RESULTS:

Eighty-eight patients with acute UAI were enrolled including 55 men and 34 women, median age of 31 years (range 10 months to 82 years). One patient (1.1%) tested positive. Among 96 patients operated for HNC, zero tested positive. The number of referrals for HNC workup, and patient encounters for peritonsillar abscesses, decreased markedly in the first 3 weeks.

CONCLUSION:

The prevalence of SARS-CoV-2 during the first 6 weeks of the first wave was minimal among patients with acute UAI and zero among patients operated for HNC. The decrease in referrals for the workup of HNC may increase time to treatment initiation and patient morbidity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Otolaryngology / COVID-19 / Head and Neck Neoplasms Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Infant / Male Country/Region as subject: Europa Language: English Journal: Eur Arch Otorhinolaryngol Journal subject: Otolaryngology Year: 2021 Document Type: Article Affiliation country: S00405-020-06514-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Otolaryngology / COVID-19 / Head and Neck Neoplasms Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Infant / Male Country/Region as subject: Europa Language: English Journal: Eur Arch Otorhinolaryngol Journal subject: Otolaryngology Year: 2021 Document Type: Article Affiliation country: S00405-020-06514-6