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Hydroxychloroquine for the treatment of COVID-19 and its potential cardiovascular toxicity: Hero or villain?
Egeli, Bugra Han; Sparks, Jeffrey A; Kim, Alfred H J; Liew, Jean W.
  • Egeli BH; Graduate Medical Sciences, Boston University School of Medicine, 72 E Concord St L-317, Boston, MA, 02118, USA. Electronic address: bhegeli@bu.edu.
  • Sparks JA; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, 60 Fenwood Road, #6016U, Boston, MA, 02115, USA. Electronic address: jsparks@bwh.harvard.edu.
  • Kim AHJ; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8045, St Louis, MO, 63110, USA. Electronic address: akim@dom.wustl.edu.
  • Liew JW; Section of Rheumatology, Boston University School of Medicine, 650 Albany St, X200, Boston, MA, 02118, USA. Electronic address: jwliew@bu.edu.
Best Pract Res Clin Rheumatol ; 35(1): 101658, 2021 03.
Article in English | MEDLINE | ID: covidwho-1002351
ABSTRACT
A variety of treatment modalities have been investigated since the beginning of the Coronavirus Disease-19 (COVID-19) pandemic. The use of antimalarials (hydroxychloroquine and chloroquine) for COVID-19 treatment and prevention has proven to be a cautionary tale for widespread, off-label use of a medication during a crisis. The investigation of antimalarials for COVID-19 has also been a driver for a deluge of scientific output in a short amount of time. In this narrative review, we detail the evidence for and against antimalarial use in COVID-19, starting with the early small observational studies that influenced strategies worldwide. We then contrast these findings to later published larger observational studies and randomized controlled trials. We detail the emerging possible cardiovascular risks associated with antimalarial use in COVID-19 and whether COVID-19-related outcomes and cardiovascular risks may differ for antimalarials used in rheumatic diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Coronavirus Infections / Cardiotoxicity / COVID-19 Drug Treatment / Hydroxychloroquine Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Language: English Journal: Best Pract Res Clin Rheumatol Journal subject: Rheumatology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Coronavirus Infections / Cardiotoxicity / COVID-19 Drug Treatment / Hydroxychloroquine Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Language: English Journal: Best Pract Res Clin Rheumatol Journal subject: Rheumatology Year: 2021 Document Type: Article