Unable to open log file for update ../../bases/logs/gimorg/logerror.txtUnable to open log file for update ../../bases/logs/gimorg/logerror.txt Clinically distinct COVID-19 cases share notably similar immune response progression: A follow-up analysis. | Heliyon;7(1): e05877, 2021 Jan. | MEDLINE
Clinically distinct COVID-19 cases share notably similar immune response progression: A follow-up analysis.
Hausburg, Melissa A; Banton, Kaysie L; Roshon, Michael; Bar-Or, David.
  • Hausburg MA; Trauma Research Department, Swedish Medical Center, Englewood, CO, USA.
  • Banton KL; Trauma Research Department, St. Anthony Hospital, Lakewood, CO, USA.
  • Roshon M; Trauma Research Department, Penrose Hospital, Colorado Springs, CO, USA.
  • Bar-Or D; Emergency Room Department, Penrose Hospital, Colorado Springs, CO, USA.
Heliyon ; 7(1): e05877, 2021 Jan.
Article in English | MEDLINE | ID: covidwho-1002561
Preprint
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Semantic information from SemMedBD (by NLM)
1. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. Complement C1 Inactivator Proteins STIMULATES C1 esterase inhibitor|SERPING1
Subject
Complement C1 Inactivator Proteins
Predicate
STIMULATES
Object
C1 esterase inhibitor|SERPING1
4. Serum LOCATION_OF SERPING1 gene|SERPING1
Subject
Serum
Predicate
LOCATION_OF
Object
SERPING1 gene|SERPING1
5. Signs and Symptoms PROCESS_OF Patients
Subject
Signs and Symptoms
Predicate
PROCESS_OF
Object
Patients
6. Clot formation USES Fibrin
Subject
Clot formation
Predicate
USES
Object
Fibrin
7. Transcript INTERACTS_WITH Interferons
Subject
Transcript
Predicate
INTERACTS_WITH
Object
Interferons
8. Symptom mild PROCESS_OF Persons
Subject
Symptom mild
Predicate
PROCESS_OF
Object
Persons
9. Immune response AFFECTS Reinfection
Subject
Immune response
Predicate
AFFECTS
Object
Reinfection
10. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
11. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
12. Complement C1 Inactivator Proteins STIMULATES C1 esterase inhibitor|SERPING1
Subject
Complement C1 Inactivator Proteins
Predicate
STIMULATES
Object
C1 esterase inhibitor|SERPING1
13. Serum LOCATION_OF SERPING1 gene|SERPING1
Subject
Serum
Predicate
LOCATION_OF
Object
SERPING1 gene|SERPING1
14. Signs and Symptoms PROCESS_OF Patients
Subject
Signs and Symptoms
Predicate
PROCESS_OF
Object
Patients
15. Clot formation USES Fibrin
Subject
Clot formation
Predicate
USES
Object
Fibrin
16. Transcript INTERACTS_WITH Interferons
Subject
Transcript
Predicate
INTERACTS_WITH
Object
Interferons
17. Symptom mild PROCESS_OF Persons
Subject
Symptom mild
Predicate
PROCESS_OF
Object
Persons
18. Immune response AFFECTS Reinfection
Subject
Immune response
Predicate
AFFECTS
Object
Reinfection
ABSTRACT
Inflammatory responses to the novel coronavirus SARS-CoV-2, which causes COVID-19, range from asymptomatic to severe. Here we present a follow-up analysis of a longitudinal study characterizing COVID-19 immune responses from a father and son with distinctly different clinical courses. The father required a lengthy hospital stay for severe symptoms, whereas his son had mild symptoms and no fever yet tested positive for SARS-CoV-2 for 29 days. Father and son, as well as another unrelated COVID-19 patient, displayed a robust increase of SERPING1, the transcript encoding C1 esterase inhibitor (C1-INH). We further bolstered this finding by incorporating a serum proteomics dataset and found that serum C1-INH was consistently increased in COVID-19 patients. C1-INH is a central regulator of the contact and complement systems, potentially linking COVID-19 to complement hyperactivation, fibrin clot formation, and immune depression. Furthermore, despite distinct clinical cases, significant parallels were observed in transcripts involved in interferon and B cell signaling. As symptoms were resolving, widespread decreases were seen in immune-related transcripts to levels below those of healthy controls. Our study provides insight into the immune responses of likely millions of people with extremely mild symptoms who may not be aware of their infection with SARS-CoV-2 and implies a potential for long-lasting consequences that could contribute to reinfection risk.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Risk factors Topics: Long Covid Language: English Journal: Heliyon Year: 2021 Document Type: Article Affiliation country: J.heliyon.2020.e05877

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Risk factors Topics: Long Covid Language: English Journal: Heliyon Year: 2021 Document Type: Article Affiliation country: J.heliyon.2020.e05877