Clinically distinct COVID-19 cases share notably similar immune response progression: A follow-up analysis.
Heliyon
; 7(1): e05877, 2021 Jan.
Article
in English
| MEDLINE | ID: covidwho-1002561
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
Semantic information from SemMedBD (by NLM)
1. 2019 novel coronavirus CAUSES COVID-19
2. COVID-19 PROCESS_OF Patients
3. Complement C1 Inactivator Proteins STIMULATES C1 esterase inhibitor|SERPING1
4. Serum LOCATION_OF SERPING1 gene|SERPING1
5. Signs and Symptoms PROCESS_OF Patients
6. Clot formation USES Fibrin
7. Transcript INTERACTS_WITH Interferons
8. Symptom mild PROCESS_OF Persons
9. Immune response AFFECTS Reinfection
10. 2019 novel coronavirus CAUSES COVID-19
11. COVID-19 PROCESS_OF Patients
12. Complement C1 Inactivator Proteins STIMULATES C1 esterase inhibitor|SERPING1
13. Serum LOCATION_OF SERPING1 gene|SERPING1
14. Signs and Symptoms PROCESS_OF Patients
15. Clot formation USES Fibrin
16. Transcript INTERACTS_WITH Interferons
17. Symptom mild PROCESS_OF Persons
18. Immune response AFFECTS Reinfection
ABSTRACT
Inflammatory responses to the novel coronavirus SARS-CoV-2, which causes COVID-19, range from asymptomatic to severe. Here we present a follow-up analysis of a longitudinal study characterizing COVID-19 immune responses from a father and son with distinctly different clinical courses. The father required a lengthy hospital stay for severe symptoms, whereas his son had mild symptoms and no fever yet tested positive for SARS-CoV-2 for 29 days. Father and son, as well as another unrelated COVID-19 patient, displayed a robust increase of SERPING1, the transcript encoding C1 esterase inhibitor (C1-INH). We further bolstered this finding by incorporating a serum proteomics dataset and found that serum C1-INH was consistently increased in COVID-19 patients. C1-INH is a central regulator of the contact and complement systems, potentially linking COVID-19 to complement hyperactivation, fibrin clot formation, and immune depression. Furthermore, despite distinct clinical cases, significant parallels were observed in transcripts involved in interferon and B cell signaling. As symptoms were resolving, widespread decreases were seen in immune-related transcripts to levels below those of healthy controls. Our study provides insight into the immune responses of likely millions of people with extremely mild symptoms who may not be aware of their infection with SARS-CoV-2 and implies a potential for long-lasting consequences that could contribute to reinfection risk.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Observational study
/
Risk factors
Topics:
Long Covid
Language:
English
Journal:
Heliyon
Year:
2021
Document Type:
Article
Affiliation country:
J.heliyon.2020.e05877