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Inactivating SARS-CoV-2 by electrochemical oxidation.
Tu, Yunchuan; Tang, Wei; Yu, Liang; Liu, Zheyi; Liu, Yanting; Xia, Huicong; Zhang, Haiwei; Chen, Shiyun; Wu, Jia; Cui, Xiaoju; Zhang, Jianan; Wang, Fangjun; Hu, Yangbo; Deng, Dehui.
  • Tu Y; State Key Laboratory of Catalysis, Collaborative Innovation Center of Chemistry for Energy Materials, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
  • Tang W; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Yu L; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China.
  • Liu Z; State Key Laboratory of Catalysis, Collaborative Innovation Center of Chemistry for Energy Materials, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
  • Liu Y; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Xia H; CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
  • Zhang H; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Chen S; State Key Laboratory of Catalysis, Collaborative Innovation Center of Chemistry for Energy Materials, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
  • Wu J; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Cui X; College of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China.
  • Zhang J; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China.
  • Wang F; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China.
  • Hu Y; Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China.
  • Deng D; State Key Laboratory of Catalysis, Collaborative Innovation Center of Chemistry for Energy Materials, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Sci Bull (Beijing) ; 66(7): 720-726, 2021 Apr 15.
Article in English | MEDLINE | ID: covidwho-1003043
ABSTRACT
Fully inactivating SARS-CoV-2, the virus causing coronavirus disease 2019, is of key importance for interrupting virus transmission but is currently performed by using biologically or environmentally hazardous disinfectants. Herein, we report an eco-friendly and efficient electrochemical strategy for inactivating the SARS-CoV-2 using in-situ formed nickel oxide hydroxide as anode catalyst and sodium carbonate as electrolyte. At a voltage of 5 V, the SARS-CoV-2 viruses can be rapidly inactivated with disinfection efficiency reaching 95% in only 30 s and 99.99% in 5 min. Mass spectrometry analysis and theoretical calculations indicate that the reactive oxygen species generated on the anode can oxidize the peptide chains and induce cleavage of the peptide backbone of the receptor binding domain of the SARS-CoV-2 spike glycoprotein, and thereby disables the virus. This strategy provides a sustainable and highly efficient approach for the disinfection of the SARS-CoV-2 viruliferous aerosols and wastewater.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Sci Bull (Beijing) Year: 2021 Document Type: Article Affiliation country: J.scib.2020.12.025

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Sci Bull (Beijing) Year: 2021 Document Type: Article Affiliation country: J.scib.2020.12.025