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Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques.
Ishigaki, Hirohito; Nakayama, Misako; Kitagawa, Yoshinori; Nguyen, Cong Thanh; Hayashi, Kaori; Shiohara, Masanori; Gotoh, Bin; Itoh, Yasushi.
  • Ishigaki H; Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
  • Nakayama M; Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
  • Kitagawa Y; Division of Microbiology and Infectious Diseases, Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
  • Nguyen CT; Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
  • Hayashi K; Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan; Department of Obstetrics and Gynecology, Shiga University of Medical Science, Otsu, Japan.
  • Shiohara M; Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
  • Gotoh B; Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
  • Itoh Y; Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan. Electronic address: yasushii@belle.shiga-med.ac.jp.
Virology ; 554: 97-105, 2021 02.
Article in English | MEDLINE | ID: covidwho-1003123
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ABSTRACT
We examined the pathogenicity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in cynomolgus macaques for 28 days to establish an animal model of COVID-19 for the development of vaccines and antiviral drugs. Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. A neutralizing antibody against SARS-CoV-2 and T-lymphocytes producing interferon (IFN)-γ specifically for SARS-CoV-2 N-protein were detected on day 14 in one of three macaques with viral pneumonia. In the other two macaques, in which a neutralizing antibody was not detected, T-lymphocytes producing IFN-γ specifically for SARS-CoV-2 N protein increased on day 7 to day 14, suggesting that not only a neutralizing antibody but also cellular immunity has a role in the elimination of SARS-CoV-2. Thus, because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: T-Lymphocytes / Disease Models, Animal / Antibodies, Neutralizing / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Long Covid / Vaccines Limits: Animals Language: English Journal: Virology Year: 2021 Document Type: Article Affiliation country: J.virol.2020.12.013

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Full text: Available Collection: International databases Database: MEDLINE Main subject: T-Lymphocytes / Disease Models, Animal / Antibodies, Neutralizing / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Long Covid / Vaccines Limits: Animals Language: English Journal: Virology Year: 2021 Document Type: Article Affiliation country: J.virol.2020.12.013