Your browser doesn't support javascript.
The use of methylprednisolone in COVID-19 patients: A propensity score matched retrospective cohort study.
You, Xiang; Wu, Chao-Hui; Fu, Ya-Nan; He, Zonglin; Huang, Pin-Fang; Chen, Gong-Ping; Lin, Cui-Hong; Ming, Wai-Kit; Lin, Rong-Fang.
  • You X; Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
  • Wu CH; Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
  • Fu YN; Department of Pharmacy, Yichang Third People's Hospital, Yichang, China.
  • He Z; Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
  • Huang PF; Faculty of Medicine, International School, Jinan University, Guangzhou, China.
  • Chen GP; Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
  • Lin CH; Respiratory Department, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
  • Ming WK; Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
  • Lin RF; Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
PLoS One ; 15(12): e0244128, 2020.
Article in English | MEDLINE | ID: covidwho-1004460
Semantic information from SemMedBD (by NLM)
1. methylprednisolone TREATS COVID-19
Subject
methylprednisolone
Predicate
TREATS
Object
COVID-19
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. methylprednisolone TREATS Patients
Subject
methylprednisolone
Predicate
TREATS
Object
Patients
4. Nucleic Acids PART_OF 2019 novel coronavirus
Subject
Nucleic Acids
Predicate
PART_OF
Object
2019 novel coronavirus
5. Laboratory Procedures USES Nasal Swab (procedure)
Subject
Laboratory Procedures
Predicate
USES
Object
Nasal Swab (procedure)
6. methylprednisolone ADMINISTERED_TO Patients
Subject
methylprednisolone
Predicate
ADMINISTERED_TO
Object
Patients
7. Nucleic Acids ADMINISTERED_TO Patients
Subject
Nucleic Acids
Predicate
ADMINISTERED_TO
Object
Patients
8. Nucleic Acids compared_with methylprednisolone
Subject
Nucleic Acids
Predicate
compared_with
Object
methylprednisolone
9. Uncertainty PROCESS_OF Patients
Subject
Uncertainty
Predicate
PROCESS_OF
Object
Patients
10. methylprednisolone TREATS COVID-19
Subject
methylprednisolone
Predicate
TREATS
Object
COVID-19
11. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
12. methylprednisolone TREATS Patients
Subject
methylprednisolone
Predicate
TREATS
Object
Patients
13. Nucleic Acids PART_OF 2019 novel coronavirus
Subject
Nucleic Acids
Predicate
PART_OF
Object
2019 novel coronavirus
14. Laboratory Procedures USES Nasal Swab (procedure)
Subject
Laboratory Procedures
Predicate
USES
Object
Nasal Swab (procedure)
15. methylprednisolone ADMINISTERED_TO Patients
Subject
methylprednisolone
Predicate
ADMINISTERED_TO
Object
Patients
16. Nucleic Acids ADMINISTERED_TO Patients
Subject
Nucleic Acids
Predicate
ADMINISTERED_TO
Object
Patients
17. Nucleic Acids compared_with methylprednisolone
Subject
Nucleic Acids
Predicate
compared_with
Object
methylprednisolone
18. Uncertainty PROCESS_OF Patients
Subject
Uncertainty
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

PURPOSE:

To evaluate the efficacy and safety of methylprednisolone in treating the coronavirus disease 2019 (COVID-19) patients.

METHODS:

A retrospective cohort study was conducted, and all COVID-19 patients were recruited who were admitted to the Yichang Third People's Hospital from February 1st to March 31st, 2020. One-to-one propensity score matching (PSM) was used for minimizing confounding effects. The primary outcome was hospital mortality, with the secondary outcomes being the time needed for a positive SARS-CoV-2 nucleic acid test to turn negative and the length of hospital stay.

RESULTS:

Totaling 367 patients with COVID-19 hospitalized at the Yichang Third People's Hospital were identified, of whom 276 were mild or stable COVID-19, and 67 were serious or critically ill. Among them, 255 patients were treated using methylprednisolone, and 188 did not receive any corticosteroid-related treatment. After PSM, no statistically significant difference was found in the baseline characteristics between the two groups. Regarding the outcomes, there also were no statistically significant difference between the two groups. Patients without the use of methylprednisolone were more quickly to obtain negative results of their nasopharyngeal swab tests of SARS-CoV-2 nucleic acid after treatment, compared to those receiving methylprednisolone.

CONCLUSION:

Methylprednisolone could not improve the prognosis of patients with COVID-19, and the efficacy and safety of the use of methylprednisolone in patients with COVID-19 still remain uncertain, thus the use of corticosteroids clinically in patients with COVID-19 should be with cautions.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Methylprednisolone / Hospital Mortality / SARS-CoV-2 / COVID-19 / Length of Stay Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2020 Document Type: Article Affiliation country: Journal.pone.0244128

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Methylprednisolone / Hospital Mortality / SARS-CoV-2 / COVID-19 / Length of Stay Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2020 Document Type: Article Affiliation country: Journal.pone.0244128