NOX-Dependent Signaling Dysregulation in Severe COVID-19: Clues to Effective Treatments.

Damiano, Simona; Sozio, Concetta; La Rosa, Giuliana; Santillo, Mariarosaria

Damiano, Simona; Sozio, Concetta; La Rosa, Giuliana; Santillo, Mariarosaria.

Damiano S; Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli "Federico II", Napoli, Italy.
Sozio C; Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli "Federico II", Napoli, Italy.
La Rosa G; Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli "Federico II", Napoli, Italy.
Santillo M; Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli "Federico II", Napoli, Italy.

Front Cell Infect Microbiol ; 10: 608435, 2020.

Article in English | MEDLINE | ID: covidwho-1004674

Subject(s)

COVID-19/metabolism; NADPH Oxidases/physiology; Oxidative Stress; SARS-CoV-2; Signal Transduction/physiology; Angiotensin-Converting Enzyme 2/metabolism; COVID-19/epidemiology; Cardiovascular Diseases/enzymology; Cardiovascular Diseases/epidemiology; Comorbidity; Diabetes Mellitus, Type 2/enzymology; Diabetes Mellitus, Type 2/epidemiology; Enzyme Activation; Enzyme Inhibitors/pharmacology; Enzyme Inhibitors/therapeutic use; Humans; Metformin/pharmacology; Metformin/therapeutic use; NADPH Oxidase 2/physiology; Obesity/enzymology; Obesity/epidemiology; Oxidation-Reduction; Proto-Oncogene Mas; Proto-Oncogene Proteins/metabolism; Reactive Oxygen Species/metabolism; Receptors, G-Protein-Coupled/metabolism; Receptors, Virus/metabolism; Renin-Angiotensin System; SARS-CoV-2/physiology; COVID-19 Drug Treatment

Keywords

NOX enzymes; angiotensin converting enzyme 2; cardiovascular diseases; coronavirus disease 2019; diabetes; hypertension; obesity; severe acute respiratory syndrome coronavirus 2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Signal Transduction / Oxidative Stress / NADPH Oxidases / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study Limits: Humans Language: English Journal: Front Cell Infect Microbiol Year: 2020 Document Type: Article Affiliation country: Fcimb.2020.608435

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