[Structural characteristics and catalytic cycle of dihydroorotate dehydrogenase-a review].
Sheng Wu Gong Cheng Xue Bao
; 36(12): 2732-2740, 2020 Dec 25.
Article
in Chinese
| MEDLINE | ID: covidwho-1005126
ABSTRACT
Dihydroorotate dehydrogenase is a flavin-dependent mitochondrial enzyme to catalyze the fourth step of the de novo synthesis of pyrimidine and to oxidize dihydroorotate to orotate. By selectively inhibiting dihydroorotate dehydrogenase, thereby inhibiting pyrimidine synthesis, the enzyme has been developed for the treatment of cancer, autoimmune diseases, bacterial or viral infections, parasitic diseases and so on. The development of inhibitory drugs requires a detailed understanding of the structural characteristics and catalytic cycle mechanism of dihydroorotate dehydrogenase. Therefore, this paper reviews these two aspects, and indicates perspectives of these inhibitors in clinical application.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Oxidoreductases Acting on CH-CH Group Donors
Type of study:
Prognostic study
Language:
Chinese
Journal:
Sheng Wu Gong Cheng Xue Bao
Journal subject:
Biotechnology
Year:
2020
Document Type:
Article
Affiliation country:
J.cjb.200166
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