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Early Impact of COVID-19 on Solid Organ Transplantation in the United States.
Cholankeril, George; Podboy, Alexander; Alshuwaykh, Omar S; Kim, Donghee; Kanwal, Fasiha; Esquivel, Carlos O; Ahmed, Aijaz.
  • Cholankeril G; Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Redwood City, CA.
  • Podboy A; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA.
  • Alshuwaykh OS; Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Redwood City, CA.
  • Kim D; Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Redwood City, CA.
  • Kanwal F; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA.
  • Esquivel CO; Division of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, TX.
  • Ahmed A; Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA.
Transplantation ; 104(11): 2221-2224, 2020 11.
Article in English | MEDLINE | ID: covidwho-1005670
ABSTRACT

BACKGROUND:

The regional impact of coronavirus disease 2019 on solid organ transplantation in the United States has not been fully evaluated.

METHODS:

A retrospective analysis of month-to-month trends on waitlist additions, waitlist deaths, and transplant surgeries between all United Network for Organ Sharing (UNOS) regions was performed. A linear regression model trained on historical data was used to estimate anticipated transplantation volume.

RESULTS:

All UNOS regions reported a decrease in total waitlist additions and transplant surgeries. The largest decreases in total transplants were identified in regions 1, 2, 6, and 9, with regions 2, 7, 8, and 9 noting the largest decrease in waitlist additions. Six of the 11 regions noted increases in waitlist deaths, with UNOS regions 9, 1, and 2, all located within the Northeast, noting the highest percent increase in waitlist deaths at 170%, 89%, and 54%, respectively. The largest reductions in solid organ transplantation and waitlist deaths were seen in kidney and lung transplantation. Current transplantation volume is significantly lower than the low range of the 95% confidence interval derived from the linear regression model (2182 versus 3110; P < 0.05).

CONCLUSIONS:

Significant decreases in total waitlist additions and transplant surgeries with increases in waitlist deaths were noted in the majority of US transplant domains. The impact was especially prevalent in areas with high burden of coronavirus disease 2019 infection. National and regional strategies aimed at minimizing disruptions in transplantation are needed.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Waiting Lists / Organ Transplantation / Coronavirus Infections Type of study: Experimental Studies / Observational study Limits: Humans Country/Region as subject: North America Language: English Journal: Transplantation Year: 2020 Document Type: Article Affiliation country: TP.0000000000003391

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Waiting Lists / Organ Transplantation / Coronavirus Infections Type of study: Experimental Studies / Observational study Limits: Humans Country/Region as subject: North America Language: English Journal: Transplantation Year: 2020 Document Type: Article Affiliation country: TP.0000000000003391