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Coronavirus Disease 2019, Superinfections, and Antimicrobial Development: What Can We Expect?
Clancy, Cornelius J; Nguyen, M Hong.
  • Clancy CJ; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Nguyen MH; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Clin Infect Dis ; 71(10): 2736-2743, 2020 12 17.
Article in English | MEDLINE | ID: covidwho-1005680
ABSTRACT
Coronavirus disease 2019 (COVID-19) arose at a time of great concern about antimicrobial resistance (AMR). No studies have specifically assessed COVID-19-associated superinfections or AMR. Based on limited data from case series, it is reasonable to anticipate that an appreciable minority of patients with severe COVID-19 will develop superinfections, most commonly pneumonia due to nosocomial bacteria and Aspergillus. Microbiology and AMR patterns are likely to reflect institutional ecology. Broad-spectrum antimicrobial use is likely to be widespread among hospitalized patients, both as directed and empiric therapy. Stewardship will have a crucial role in limiting unnecessary antimicrobial use and AMR. Congressional COVID-19 relief bills are considering antimicrobial reimbursement reforms and antimicrobial subscription models, but it is unclear if these will be included in final legislation. Prospective studies on COVID-19 superinfections are needed, data from which can inform rational antimicrobial treatment and stewardship strategies, and models for market reform and sustainable drug development.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Superinfection / COVID-19 / Anti-Infective Agents Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Superinfection / COVID-19 / Anti-Infective Agents Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: Cid