Association of elevated inflammatory markers and severe COVID-19: A meta-analysis.
Medicine (Baltimore)
; 99(47): e23315, 2020 Nov 20.
Article
in English
| MEDLINE | ID: covidwho-1005842
ABSTRACT
Our study aimed to assess the existing evidence on whether severe coronavirus disease 2019 (COVID-19) is associated with elevated inflammatory markers.The PubMed, Embase, Web of Science, Scopus, Chinese National Knowledge Infrastructure, WanFang, and China Science and Technology Journal databases were searched to identify studies published between January 1 and April 21, 2020 that assayed inflammatory markers in COVID-19 patients. Three reviewers independently examined the literature, extracted relevant data, and assessed the risk of publication bias before including the meta-analysis studies.Fifty-six studies involving 8719 COVID-19 patients were identified. Meta-analysis showed that patients with severe disease showed elevated levels of white blood cell count (WMD 1.15, 95% CI 0.78-1.52), C-reactive protein (WMD 38.85, 95% CI 31.19-46.52), procalcitonin (WMD 0.08, 95% CI 0.06-0.11), erythrocyte sedimentation rate (WMD 10.15, 95% CI 5.03-15.46), interleukin-6 (WMD 23.87, 95% CI 15.95-31.78), and interleukin-10 (WMD 2.12, 95% CI 1.97-2.28). Similarly, COVID-19 patients who died during follow-up showed significantly higher levels of white blood cell count (WMD 4.11, 95% CI 3.25-4.97), C-reactive protein (WMD 74.18, 95% CI 56.63-91.73), procalcitonin (WMD 0.26, 95% CI 0.11-0.42), erythrocyte sedimentation rate (WMD 10.94, 95% CI 4.79-17.09), and interleukin-6 (WMD 59.88, 95% CI 19.46-100.30) than survivors.Severe COVID-19 is associated with higher levels of inflammatory markers than a mild disease, so tracking these markers may allow early identification or even prediction of disease progression.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Severity of Illness Index
/
Biomarkers
/
Coronavirus Infections
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Inflammation Mediators
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Betacoronavirus
Type of study:
Cohort study
/
Prognostic study
/
Reviews
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Medicine (Baltimore)
Year:
2020
Document Type:
Article
Affiliation country:
MD.0000000000023315
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