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Coronavirus diseases 2019: Current biological situation and potential therapeutic perspective.
Khan, Suliman; Tombuloglu, Huseyin; Hassanein, Sameh E; Rehman, Suriya; Bozkurt, Ayhan; Cevik, Emre; Abdel-Ghany, Shaimaa; Nabi, Ghulam; Ali, Ashaq; Sabit, Hussein.
  • Khan S; Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China.
  • Tombuloglu H; Department of Genetics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam, 31441, Saudi Arabia.
  • Hassanein SE; Bioinformatics Dept., Agricultural Genetic Engineering Research Institute (AGERI), Bioinformatics and Functional Genomics Dept., College of Biotechnology, Misr University for Science and Technology, P. O. Box 77, Giza, Egypt.
  • Rehman S; Department of Epidemic Diseases Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, 31441, Dammam, Saudi Arabia.
  • Bozkurt A; Department of Physics, Institute for Medical Research and Consultations, Imam Abdulrahman Bin Faisal University, P. O. Box: 1982, 31441, Dammam, Saudi Arabia.
  • Cevik E; Department of Genetics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam, 31441, Saudi Arabia.
  • Abdel-Ghany S; Department of Environmental Biotechnology, College of Biotechnology, Misr University for Science and Technology, P. O. Box 77, Giza, Egypt.
  • Nabi G; Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, PR China.
  • Ali A; Wuhan Institute of Virology, Chinese Academy of Sciences Xiao Hong Shan No.44, Wuhan, PR China; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Sabit H; Department of Genetics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam, 31441, Saudi Arabia. Electronic address: hhsabit@iau.edu.sa.
Eur J Pharmacol ; 886: 173447, 2020 Nov 05.
Article in English | MEDLINE | ID: covidwho-1005871
ABSTRACT
Coronavirus Disease 2019 (COVID-19) caused by a Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was first reported in Wuhan, China at the end of December 2019. SARS-CoV-2 is a highly pathogenic zoonotic virus and closely related to the Severe Acute Respiratory Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The COVID-19 was declared as a global pandemic due to its high infectiousness, and worldwide morbidities and mortalities. The Chinese scientists at the start of the outbreak reported genome sequences, which made the characterization of glycoproteins and other structural proteins possible. Moreover, researchers across the world have widely focused on understanding basic biology, developing vaccines, and therapeutic drugs against the COVID-19. However, until now, no promising treatment options, as well as vaccines, are available. In this review, we have described SARS-CoV-2's genome, transmission, and pathogenicity. We also discussed novel potential therapeutic agents that can help to treat the COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections Type of study: Diagnostic study / Observational study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Eur J Pharmacol Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections Type of study: Diagnostic study / Observational study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Eur J Pharmacol Year: 2020 Document Type: Article