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COVID-19 associated complications and potential therapeutic targets.
Monpara, Jasmin D; Sodha, Srushti J; Gupta, Pardeep K.
  • Monpara JD; University of the Sciences, 600 South 43rd Street, Philadelphia, PA, 19104, USA. Electronic address: jmonpara@usciences.edu.
  • Sodha SJ; University of the Sciences, 600 South 43rd Street, Philadelphia, PA, 19104, USA.
  • Gupta PK; University of the Sciences, 600 South 43rd Street, Philadelphia, PA, 19104, USA.
Eur J Pharmacol ; 886: 173548, 2020 Nov 05.
Article in English | MEDLINE | ID: covidwho-1006002
ABSTRACT
The global pandemic COVID-19, caused by novel coronavirus SARS-CoV-2, has emerged as severe public health issue crippling world health care systems. Substantial knowledge has been generated about the pathophysiology of the disease and possible treatment modalities in a relatively short span of time. As of August 19, 2020, there is no approved drug for the treatment of COVID-19. More than 600 clinical trials for potential therapeutics are underway and the results are expected soon. Based on early experience, different treatment such as anti-viral drugs (remdesivir, favipiravir, lopinavir/ritonavir), corticosteroids (methylprednisolone, dexamethasone) or convalescent plasma therapy are recommended in addition to supportive care and symptomatic therapy. There are several treatments currently being investigated to address the pathological conditions associated with COVID-19. This review provides currently available information and insight into pathophysiology of the disease, potential targets, and relevant clinical trials for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Molecular Targeted Therapy Type of study: Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Eur J Pharmacol Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Molecular Targeted Therapy Type of study: Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Eur J Pharmacol Year: 2020 Document Type: Article