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Effects of COVID-19 Lockdown on Movement Disorders Patients With Deep Brain Stimulation: A Multicenter Survey.
Piano, Carla; Bove, Francesco; Tufo, Tommaso; Imbimbo, Isabella; Genovese, Danilo; Stefani, Alessandro; Marano, Massimo; Peppe, Antonella; Brusa, Livia; Cerroni, Rocco; Motolese, Francesco; Di Stasio, Enrico; Mazza, Marianna; Daniele, Antonio; Olivi, Alessandro; Calabresi, Paolo; Bentivoglio, Anna Rita.
  • Piano C; Neurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Bove F; Neurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Tufo T; Department of Neurosciences, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Imbimbo I; Neurosurgery Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Genovese D; Neurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Stefani A; Fondazione Don Carlo Gnocchi Onlus, Milan, Italy.
  • Marano M; Neurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Peppe A; Department of Neurosciences, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Brusa L; Department of System Medicine, Unità Operativa Semplice Dipartimentale (UOSD) Parkinson, University of Rome Tor Vergata, Rome, Italy.
  • Cerroni R; Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy.
  • Motolese F; IRCCS Santa Lucia Foundation, Rome, Italy.
  • Di Stasio E; Neurology Unit, S. Eugenio Hospital, Rome, Italy.
  • Mazza M; Department of System Medicine, Unità Operativa Semplice Dipartimentale (UOSD) Parkinson, University of Rome Tor Vergata, Rome, Italy.
  • Daniele A; Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy.
  • Olivi A; Unit of Chemistry, Biochemistry and Clinical Molecular Biology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Calabresi P; Institute of Biochemistry and Clinical Biochemistry, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Bentivoglio AR; Department of Geriatrics, Neuroscience and Orthopedics, Institute of Psychiatry and Psychology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Front Neurol ; 11: 616550, 2020.
Article in English | MEDLINE | ID: covidwho-1006082
Semantic information from SemMedBD (by NLM)
1. Movement Disorders PROCESS_OF Patients
Subject
Movement Disorders
Predicate
PROCESS_OF
Object
Patients
2. Deep Brain Stimulation AFFECTS Patients
Subject
Deep Brain Stimulation
Predicate
AFFECTS
Object
Patients
3. Increased risk PROCESS_OF Patients
Subject
Increased risk
Predicate
PROCESS_OF
Object
Patients
4. Patients USES Implants
Subject
Patients
Predicate
USES
Object
Implants
5. Parkinson Disease AFFECTS Patients
Subject
Parkinson Disease
Predicate
AFFECTS
Object
Patients
6. COVID-19 NEG_PROCESS_OF Patients
Subject
COVID-19
Predicate
NEG_PROCESS_OF
Object
Patients
7. Psychiatric symptom ASSOCIATED_WITH Parkinson Disease
Subject
Psychiatric symptom
Predicate
ASSOCIATED_WITH
Object
Parkinson Disease
8. Deep Brain Stimulation TREATS Patients
Subject
Deep Brain Stimulation
Predicate
TREATS
Object
Patients
9. Movement Disorders PROCESS_OF Patients
Subject
Movement Disorders
Predicate
PROCESS_OF
Object
Patients
10. Deep Brain Stimulation AFFECTS Patients
Subject
Deep Brain Stimulation
Predicate
AFFECTS
Object
Patients
11. Increased risk PROCESS_OF Patients
Subject
Increased risk
Predicate
PROCESS_OF
Object
Patients
12. Patients USES Implants
Subject
Patients
Predicate
USES
Object
Implants
13. Parkinson Disease AFFECTS Patients
Subject
Parkinson Disease
Predicate
AFFECTS
Object
Patients
14. COVID-19 NEG_PROCESS_OF Patients
Subject
COVID-19
Predicate
NEG_PROCESS_OF
Object
Patients
15. Psychiatric symptom ASSOCIATED_WITH Parkinson Disease
Subject
Psychiatric symptom
Predicate
ASSOCIATED_WITH
Object
Parkinson Disease
16. Deep Brain Stimulation TREATS Patients
Subject
Deep Brain Stimulation
Predicate
TREATS
Object
Patients
ABSTRACT

Background:

The containment measures taken by Italian government authorities during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic caused the interruption of neurological activities of outpatient clinics. Vulnerable patients, as Parkinson's disease (PD) and dystonic patients with deep brain stimulation (DBS), may have an increased risk of chronic stress related to social restriction measures and may show a potential worsening of motor and psychiatric symptoms.

Methods:

This cross-sectional multicenter study was carried out during the SARS-CoV-2 pandemic and was based on a structured survey administered during a telephone call. The questionnaire was designed to gather motor and/or psychiatric effects of the lockdown and coronavirus disease 2019 (COVID-19) epidemiologic information in PD and dystonic patients with a functioning DBS implant.

Results:

One hundred four patients were included in the study, 90 affected by PD and 14 by dystonia. Forty-nine patients reported a subjective perception of worsening of global neurological symptoms (motor and/or psychiatric) related to the containment measures. In the multivariate analysis, having problems with the DBS device was the only independent predictor of motor worsening [odds ratio (OR) = 3.10 (1.22-7.91), p = 0.018]. Independent predictors of psychiatric worsening were instrumental activities of daily living (IADL) score [OR = 0.78 (0.64-0.95), p = 0.012] and problems with DBS [OR = 5.69 (1.95-16.62), p = 0.001]. Only one patient underwent nasopharyngeal swabs, both negative, and no patient received a diagnosis of COVID-19.

Conclusions:

Lockdown restriction measures were associated with subjective worsening of motor and psychiatric symptoms in PD and dystonic patients treated with DBS, and they may have exacerbated the burden of neurological disease and increased the chronic stress related to the DBS management.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Qualitative research / Randomized controlled trials Language: English Journal: Front Neurol Year: 2020 Document Type: Article Affiliation country: Fneur.2020.616550

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Qualitative research / Randomized controlled trials Language: English Journal: Front Neurol Year: 2020 Document Type: Article Affiliation country: Fneur.2020.616550