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Potential Medicinal Plants for the Treatment of Dengue Fever and Severe Acute Respiratory Syndrome-Coronavirus.
Saleh, Mohammed S M; Kamisah, Yusof.
  • Saleh MSM; Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Cheras 56000, Kuala Lumpur, Malaysia.
  • Kamisah Y; Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Cheras 56000, Kuala Lumpur, Malaysia.
Biomolecules ; 11(1)2020 Dec 30.
Article in English | MEDLINE | ID: covidwho-1006314
ABSTRACT
While dengue virus (DENV) infection imposes a serious challenge to the survival of humans worldwide, severe acute respiratory syndrome-coronavirus (SARS-CoV) remains the most devastating pandemic in human history. A significant number of studies have shown that plant-derived substances could serve as potential candidates for the development of safe and efficacious remedies for combating these diseases. Different scientific databases were used to source for literature on plants used against these infections. Thirty-five studies described the traditional use of 25 species from 20 families for treating DENV infection with Carica papaya and Euphorbia hirta were the most widely used across different regions. 13 in vivo studies, 32 in vitro studies, and eight clinical studies were conducted on 30 species from 25 families against different DENV serotypes, while plants from 13 families were reported to inhibit different forms of SARS-CoV, all of which were investigated through in vitro studies. Phytoconstituents belonging to various chemical classes were identified to show a wide range of antiviral activity against these infections. Extensive studies on the potentials of medicinal plants are needed to confirm their efficacy. This paper reveals the capabilities of medicinal plants and their phytochemicals in inhibiting DENV and SARS-CoV infections.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plants, Medicinal / Carica / Euphorbia / Severe Acute Respiratory Syndrome / Dengue / Dengue Virus / Severe acute respiratory syndrome-related coronavirus / Phytochemicals Type of study: Prognostic study Topics: Traditional medicine Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Biom11010042

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plants, Medicinal / Carica / Euphorbia / Severe Acute Respiratory Syndrome / Dengue / Dengue Virus / Severe acute respiratory syndrome-related coronavirus / Phytochemicals Type of study: Prognostic study Topics: Traditional medicine Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Biom11010042