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The role of Neuropilin-1 in COVID-19.
Mayi, Bindu S; Leibowitz, Jillian A; Woods, Arden T; Ammon, Katherine A; Liu, Alphonse E; Raja, Aarti.
  • Mayi BS; Department of Basic Sciences, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Clearwater, Florida, United States of America.
  • Leibowitz JA; Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, Florida, United States of America.
  • Woods AT; Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, Florida, United States of America.
  • Ammon KA; USF Morsani College of Medicine, Tampa, Florida, United States of America.
  • Liu AE; Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, Florida, United States of America.
  • Raja A; Department of Biological Sciences, Halmos College of Arts and Sciences, Nova Southeastern University, Fort Lauderdale, Florida, United States of America.
PLoS Pathog ; 17(1): e1009153, 2021 01.
Article in English | MEDLINE | ID: covidwho-1006381
ABSTRACT
Neuropilin-1 (NRP-1), a member of a family of signaling proteins, was shown to serve as an entry factor and potentiate SARS Coronavirus 2 (SARS-CoV-2) infectivity in vitro. This cell surface receptor with its disseminated expression is important in angiogenesis, tumor progression, viral entry, axonal guidance, and immune function. NRP-1 is implicated in several aspects of a SARS-CoV-2 infection including possible spread through the olfactory bulb and into the central nervous system and increased NRP-1 RNA expression in lungs of severe Coronavirus Disease 2019 (COVID-19). Up-regulation of NRP-1 protein in diabetic kidney cells hint at its importance in a population at risk of severe COVID-19. Involvement of NRP-1 in immune function is compelling, given the role of an exaggerated immune response in disease severity and deaths due to COVID-19. NRP-1 has been suggested to be an immune checkpoint of T cell memory. It is unknown whether involvement and up-regulation of NRP-1 in COVID-19 may translate into disease outcome and long-term consequences, including possible immune dysfunction. It is prudent to further research NRP-1 and its possibility of serving as a therapeutic target in SARS-CoV-2 infections. We anticipate that widespread expression, abundance in the respiratory and olfactory epithelium, and the functionalities of NRP-1 factor into the multiple systemic effects of COVID-19 and challenges we face in management of disease and potential long-term sequelae.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neuropilin-1 / Virus Internalization / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: PLoS Pathog Year: 2021 Document Type: Article Affiliation country: Journal.ppat.1009153

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neuropilin-1 / Virus Internalization / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: PLoS Pathog Year: 2021 Document Type: Article Affiliation country: Journal.ppat.1009153