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Use of Intravenous Immunoglobulins in Sepsis Therapy-A Clinical View.
Jarczak, Dominik; Kluge, Stefan; Nierhaus, Axel.
  • Jarczak D; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  • Kluge S; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  • Nierhaus A; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Int J Mol Sci ; 21(15)2020 Aug 03.
Article in English | MEDLINE | ID: covidwho-1006953
ABSTRACT
Sepsis is a life-threatening organ dysfunction, defined by a dysregulated host immune response to infection. During sepsis, the finely tuned system of immunity, inflammation and anti-inflammation is disturbed in a variety of ways. Both pro-inflammatory and anti-inflammatory pathways are upregulated, activation of the coagulation cascade and complement and sepsis-induced lymphopenia occur. Due to the manifold interactions in this network, the use of IgM-enriched intravenous immunoglobulins seems to be a promising therapeutic approach. Unfortunately, there is still a lack of evidence-based data to answer the important questions of appropriate patient populations, optimal timing and dosage of intravenous immunoglobulins. With this review, we aim to provide an overview of the role of immunoglobulins, with emphasis on IgM-enriched formulations, in the therapy of adult patients with sepsis and septic shock.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin M / Immunoglobulins, Intravenous / Sepsis / Inflammation Type of study: Prognostic study Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Ijms21155543

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin M / Immunoglobulins, Intravenous / Sepsis / Inflammation Type of study: Prognostic study Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Ijms21155543