Is nicotine exposure linked to cardiopulmonary vulnerability to COVID-19 in the general population?
FEBS J
; 287(17): 3651-3655, 2020 09.
Article
in English
| MEDLINE | ID: covidwho-10071
ABSTRACT
The recent emergence of COVID-19 has resulted in a worldwide crisis, with large populations locked down and transportation links severed. While approximately 80% of infected individuals have minimal symptoms, around 15-20% need to be hospitalized, greatly stressing global healthcare systems. As of March 10, the death rate appears to be about 3.4%, although this number is highly stratified among different populations. Here, we focus on those individuals who have been exposed to nicotine prior to their exposure to the virus. We predict that these individuals are 'primed' to be at higher risk because nicotine can directly impact the putative receptor for the virus (ACE2) and lead to deleterious signaling in lung epithelial cells.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Smoking
/
Receptors, Nicotinic
/
Pandemics
/
Spike Glycoprotein, Coronavirus
/
Angiotensin-Converting Enzyme 2
/
COVID-19
/
Nicotine
Type of study:
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
FEBS J
Journal subject:
Biochemistry
Year:
2020
Document Type:
Article
Affiliation country:
Febs.15303
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