Your browser doesn't support javascript.
In vitro characterisation of SARS-CoV-2 and susceptibility of domestic ferrets (Mustela putorius furo).
Marsh, Glenn A; McAuley, Alexander J; Brown, Sheree; Pharo, Elizabeth A; Crameri, Sandra; Au, Gough G; Baker, Michelle L; Barr, Jennifer A; Bergfeld, Jemma; Bruce, Matthew P; Burkett, Kathie; Durr, Peter A; Holmes, Clare; Izzard, Leonard; Layton, Rachel; Lowther, Suzanne; Neave, Matthew J; Poole, Timothy; Riddell, Sarah-Jane; Rowe, Brenton; Soldani, Elisha; Stevens, Vittoria; Suen, Willy W; Sundaramoorthy, Vinod; Tachedjian, Mary; Todd, Shawn; Trinidad, Lee; Williams, Sinéad M; Druce, Julian D; Drew, Trevor W; Vasan, Seshadri S.
  • Marsh GA; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • McAuley AJ; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Brown S; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Pharo EA; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Crameri S; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Au GG; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Baker ML; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Barr JA; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Bergfeld J; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Bruce MP; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Burkett K; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Durr PA; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Holmes C; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Izzard L; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Layton R; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Lowther S; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Neave MJ; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Poole T; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Riddell SJ; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Rowe B; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Soldani E; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Stevens V; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Suen WW; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Sundaramoorthy V; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Tachedjian M; School of Medicine, Deakin University, Geelong, VIC, Australia.
  • Todd S; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Trinidad L; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Williams SM; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Druce JD; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
  • Drew TW; Victorian Infectious Diseases Reference Laboratory (VIDRL), The Royal Melbourne Hospital at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Vasan SS; Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC, Australia.
Transbound Emerg Dis ; 69(2): 297-307, 2022 Mar.
Article in English | MEDLINE | ID: covidwho-1007329
ABSTRACT
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an emerging virus that has caused significant human morbidity and mortality since its detection in late 2019. With the rapid emergence has come an unprecedented programme of vaccine development with at least 300 candidates under development. Ferrets have proven to be an appropriate animal model for testing safety and efficacy of SARS-CoV-2 vaccines due to quantifiable virus shedding in nasal washes and oral swabs. Here, we outline our efforts early in the SARS-CoV-2 outbreak to propagate and characterize an Australian isolate of the virus in vitro and in an ex vivo model of human airway epithelium, as well as to demonstrate the susceptibility of domestic ferrets (Mustela putorius furo) to SARS-CoV-2 infection following intranasal challenge.
Subject(s)
Keywords
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Ferrets / COVID-19 Topics: Vaccines Limits: Animals / Humans Country/Region as subject: Oceania Language: English Journal: Transbound Emerg Dis Journal subject: Veterinary Medicine Year: 2022 Document Type: Article Affiliation country: Tbed.13978

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Ferrets / COVID-19 Topics: Vaccines Limits: Animals / Humans Country/Region as subject: Oceania Language: English Journal: Transbound Emerg Dis Journal subject: Veterinary Medicine Year: 2022 Document Type: Article Affiliation country: Tbed.13978