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SARS-CoV-2 Seroprevalence Survey Estimates Are Affected by Anti-Nucleocapsid Antibody Decline.
Bolotin, Shelly; Tran, Vanessa; Osman, Selma; Brown, Kevin A; Buchan, Sarah A; Joh, Eugene; Deeks, Shelley L; Allen, Vanessa G.
  • Bolotin S; Public Health Ontario, Toronto, Ontario, Canada.
  • Tran V; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
  • Osman S; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • Brown KA; Public Health Ontario, Toronto, Ontario, Canada.
  • Buchan SA; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • Joh E; Public Health Ontario, Toronto, Ontario, Canada.
  • Deeks SL; Public Health Ontario, Toronto, Ontario, Canada.
  • Allen VG; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
J Infect Dis ; 223(8): 1334-1338, 2021 04 23.
Article in English | MEDLINE | ID: covidwho-1007405
ABSTRACT
We analyzed 21 676 residual specimens from Ontario, Canada collected March-August 2020 to investigate the effect of antibody decline on SARS-CoV-2 seroprevalence estimates. Testing specimens orthogonally using Abbott (anti-nucleocapsid) and Ortho (anti-spike) assays, seroprevalence estimates were 0.4%-1.4%, despite ongoing disease activity. The geometric mean concentration (GMC) of antibody-positive specimens decreased over time (P = .015), and GMC of antibody-negative specimens increased over time (P = .0018). Association between the 2 tests decreased each month (P < .001), suggesting anti-nucleocapsid antibody decline. Lowering Abbott antibody index cutoff from 1.4 to 0.7 resulted in a 16% increase in positive specimens.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Nucleocapsid Proteins / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Observational study / Randomized controlled trials Limits: Humans Country/Region as subject: North America Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Nucleocapsid Proteins / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Observational study / Randomized controlled trials Limits: Humans Country/Region as subject: North America Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis