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Human Oocytes Express Both ACE2 and BSG Genes and Corresponding Proteins: Is SARS-CoV-2 Infection Possible?
Virant-Klun, Irma; Strle, Franc.
  • Virant-Klun I; Clinical Research Center, University Medical Center Ljubljana, Vrazov trg 1, Ljubljana, Slovenia. irma.virant@kclj.si.
  • Strle F; Clinical Research Center, University Medical Center Ljubljana, Vrazov trg 1, Ljubljana, Slovenia.
Stem Cell Rev Rep ; 17(1): 278-284, 2021 02.
Article in English | MEDLINE | ID: covidwho-1009199
ABSTRACT
In addition to a number of scientific and medical questions about SARS-CoV-2 infection that still need to be answered, there is also the question of how this highly virulent virus and COVID-19 disease affect gametogenesis in humans. Even more important is the question of whether the virus can also enter and infect oocytes and possibly alter them in an unknown way, which could also affect the development and status of the human embryo. The answers to these questions are still poorly known, so we reviewed the human oocyte transcriptome and proteome obtained in our previous studies and found that human oocytes from the in vitro fertilization program expressed both the ACE2 and BSG genes and the corresponding ACE2 and BSG proteins. This means that human oocytes possess the molecular 'machinery' to facilitate SARS-CoV-2 entrance and infection. According to various studies, especially in animal models, different viruses can infect oocytes, so infection of the oocyte with SARS-Cov-2 cannot be completely ruled out. A hypothetical model of human oocyte infection with this virus has been proposed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oocytes / Basigin / Angiotensin-Converting Enzyme 2 / COVID-19 Limits: Humans Language: English Journal: Stem Cell Rev Rep Year: 2021 Document Type: Article Affiliation country: S12015-020-10101-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oocytes / Basigin / Angiotensin-Converting Enzyme 2 / COVID-19 Limits: Humans Language: English Journal: Stem Cell Rev Rep Year: 2021 Document Type: Article Affiliation country: S12015-020-10101-x