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Usefulness of Plasma SARS-CoV-2 RNA Quantification by Droplet-based Digital PCR to Monitor Treatment Against COVID-19 in a B-cell Lymphoma Patient.
Szwebel, Tali-Anne; Veyer, David; Robillard, Nicolas; Eshagh, Deborah; Canoui, Etienne; Bruneau, Thomas; Contejean, Adrien; Azoulay, Celia; Serrano, Thomas; Hueso, Thomas; Izquierdo, Laure; Rozenberg, Flore; Terrier, Benjamin; Vignon, Marguerite; Laurent-Puig, Pierre; Taly, Valérie; Bélec, Laurent; Kernéis, Solen; Lacombe, Karine; Péré, Hélène.
  • Szwebel TA; Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, AP-HP CUP, Paris, France.
  • Veyer D; Service de Microbiologie (Unité de virologie), Assistance Publique Hôpitaux de Paris-Centre (AP-HP.Centre), Hôpital Européen Georges Pompidou, Paris, France.
  • Robillard N; Centre de Recherche des Cordeliers, Functional Genomics of Solid Tumors laboratory, Labex OncoImmunology, Sorbonne Université, Université de Paris, équipe labellisée Ligue Nationale contre le Cancer, Inserm, Paris, France.
  • Eshagh D; Service de Microbiologie (Unité de virologie), Assistance Publique Hôpitaux de Paris-Centre (AP-HP.Centre), Hôpital Européen Georges Pompidou, Paris, France.
  • Canoui E; Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, AP-HP CUP, Paris, France.
  • Bruneau T; Assistance Publique Hôpitaux de Paris-Centre (AP-HP.Centre), Equipe Mobile d'Infectiologie, Hôpital Cochin, Paris, France.
  • Contejean A; Service de Microbiologie (Unité de virologie), Assistance Publique Hôpitaux de Paris-Centre (AP-HP.Centre), Hôpital Européen Georges Pompidou, Paris, France.
  • Azoulay C; Personalized Medicine Pharmacogenomics, therapeutic optimization, eDIAG plateform, laboratory, équipe labellisée Ligue Nationale contre le Cancer, Labex OncoImmunology, Université de Paris, Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, Paris, France.
  • Serrano T; Assistance Publique Hôpitaux de Paris-Centre (AP-HP.Centre), Equipe Mobile d'Infectiologie, Hôpital Cochin, Paris, France.
  • Hueso T; Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, AP-HP CUP, Paris, France.
  • Izquierdo L; Service de Microbiologie (Unité de virologie), Assistance Publique Hôpitaux de Paris-Centre (AP-HP.Centre), Hôpital Européen Georges Pompidou, Paris, France.
  • Rozenberg F; Gustave Roussy Institute, Hematology Department, Paris-Saclay University, Paris, France.
  • Terrier B; Assistance Publique Hôpitaux de Paris-Centre (AP-HP.Centre), Service de Virologie, Hôpital Cochin, Paris, France.
  • Vignon M; Assistance Publique Hôpitaux de Paris-Centre (AP-HP.Centre), Service de Virologie, Hôpital Cochin, Paris, France.
  • Laurent-Puig P; Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, AP-HP CUP, Paris, France.
  • Taly V; Université de Paris PARCC, INSERM U970, Paris, France.
  • Bélec L; Assistance Publique Hôpitaux de Paris-Centre (AP-HP.Centre), Hematology Department, Hôpital Cochin, Paris, France.
  • Kernéis S; Personalized Medicine Pharmacogenomics, therapeutic optimization, eDIAG plateform, laboratory, équipe labellisée Ligue Nationale contre le Cancer, Labex OncoImmunology, Université de Paris, Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, Paris, France.
  • Lacombe K; Assistance Publique Hôpitaux de Paris-Centre (AP-HP.Centre), Service de Biochimie, Hôpital Européen Georges Pompidou, Paris, France.
  • Péré H; Personalized Medicine Pharmacogenomics, therapeutic optimization, eDIAG plateform, laboratory, équipe labellisée Ligue Nationale contre le Cancer, Labex OncoImmunology, Université de Paris, Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, Paris, France.
Stem Cell Rev Rep ; 17(1): 296-299, 2021 02.
Article in English | MEDLINE | ID: covidwho-1009200
ABSTRACT
We report the case of an HIV-1-infected patient, treated with anti-CD20 monoclonal antibody for a B-cell lymphoma previously treated by autologous stem cell transplant. He suffered from chronic COVID19 and we monitored by plasma SARS-CoV-2 RNA by highly sensitive droplet-based digital PCR technology (ddPCR). Under tocilizumab therapy and despite a first clinical improvement biologically associated with decreasing inflammatory markers, a slight increase of SARS-CoV-2 RNAaemia quantified by ddPCR was highlighted, confirming the absence of viral efficacy of this treatment and predicting the subsequent observed deterioration. As expected, his complete recovery, finally achieved after COVID-19 convalescent plasmatherapy, strictly paralleled plasma SARS-CoV-2 RNA clearance. With these results, we confirmed the interest of SARS-CoV-2 RNAaemia monitoring by ddPCR in COVID-19 patients, particularly during treatment, and firstly showed that this new and specific biomarker could be helpful to select eligible patient for anti-IL6 receptors therapy considering the variable levels of efficacy recently observed with such therapy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / HIV Infections / Lymphoma, B-Cell / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Stem Cell Rev Rep Year: 2021 Document Type: Article Affiliation country: S12015-020-10107-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / HIV Infections / Lymphoma, B-Cell / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Stem Cell Rev Rep Year: 2021 Document Type: Article Affiliation country: S12015-020-10107-5