Remdesivir therapy in patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials.
Ann Med Surg (Lond)
; 62: 43-48, 2021 Feb.
Article
in English
| MEDLINE | ID: covidwho-1009287
ABSTRACT
PURPOSE:
To perform a systematic review and meta-analysis of randomized controlled trials that examined remdesivir treatment for COVID-19. MATERIALS ANDMETHODS:
A systematic literature search was performed using Pubmed, Embase, and ClinicalTrials.gov to identify studies published up to October 25, 2020 that examined COVID-19 treatment with remdesivir. A total of 3 randomized controlled trials that consisted of 1691 patients were included in the meta-analysis.RESULTS:
The odds for mechanical ventilation (MV) or extracorporeal membrane oxygenation (ECMO) following treatment was significantly lower in the remdesivir group compared to the control group (OR = 0.48 [95% CI 0.34; 0.69], p < 0.001). The odds of early (at day 14/15; OR = 1.42 [95% CI 1.16; 1.74], p < 0.001) and late (at day 28/29; OR = 1.44 [95% CI 1.16; 1.79], p = 0.001) hospital discharge were significantly higher in the remdesivir group compared to the control group. There was no difference in the odds for mortality in patients treated with remdesivir (OR = 0.77 [95% CI 0.56; 1.06], p = 0.108).CONCLUSIONS:
Remdesivir attenuates disease progression, leading to lower odds of MV/ECMO and greater odds of hospital discharge for COVID-19 patients. However, remdesivir does not affect odds of mortality.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Language:
English
Journal:
Ann Med Surg (Lond)
Year:
2021
Document Type:
Article
Affiliation country:
J.amsu.2020.12.051
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