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Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19).
Scagnolari, Carolina; Pierangeli, Alessandra; Frasca, Federica; Bitossi, Camilla; Viscido, Agnese; Oliveto, Giuseppe; Scordio, Mirko; Mazzuti, Laura; Di Carlo, Daniele; Gentile, Massimo; Solimini, Angelo; Ceccarelli, Giancarlo; Pugliese, Francesco; Mastroianni, Claudio Maria; d'Ettorre, Gabriella; Turriziani, Ombretta; Antonelli, Guido.
  • Scagnolari C; Laboratory of Virology, Department of Molecular Medicine, Sapienza University, Affiliated to Istituto Pasteur Italia, Rome 00185, Italy. Electronic address: carolina.scagnolari@uniroma1.it.
  • Pierangeli A; Laboratory of Virology, Department of Molecular Medicine, Sapienza University, Affiliated to Istituto Pasteur Italia, Rome 00185, Italy.
  • Frasca F; Laboratory of Virology, Department of Molecular Medicine, Sapienza University, Affiliated to Istituto Pasteur Italia, Rome 00185, Italy.
  • Bitossi C; Laboratory of Virology, Department of Molecular Medicine, Sapienza University, Affiliated to Istituto Pasteur Italia, Rome 00185, Italy.
  • Viscido A; Laboratory of Virology, Department of Molecular Medicine, Sapienza University, Affiliated to Istituto Pasteur Italia, Rome 00185, Italy.
  • Oliveto G; Laboratory of Virology, Department of Molecular Medicine, Sapienza University, Affiliated to Istituto Pasteur Italia, Rome 00185, Italy.
  • Scordio M; Laboratory of Virology, Department of Molecular Medicine, Sapienza University, Affiliated to Istituto Pasteur Italia, Rome 00185, Italy.
  • Mazzuti L; Laboratory of Virology, Department of Molecular Medicine, Sapienza University, Affiliated to Istituto Pasteur Italia, Rome 00185, Italy.
  • Di Carlo D; Laboratory of Virology, Department of Molecular Medicine, Sapienza University, Affiliated to Istituto Pasteur Italia, Rome 00185, Italy.
  • Gentile M; Laboratory of Virology, Department of Molecular Medicine, Sapienza University, Affiliated to Istituto Pasteur Italia, Rome 00185, Italy.
  • Solimini A; Department of Public Health and Infectious Diseases, Sapienza University, Viale del Policlinico 155, Rome 00185, Italy.
  • Ceccarelli G; Department of Public Health and Infectious Diseases, Sapienza University, Viale del Policlinico 155, Rome 00185, Italy.
  • Pugliese F; Department of General and Specialist Surgery "Paride Stefanini", Sapienza University, Viale del Policlinico 155, Rome 00185, Italy.
  • Mastroianni CM; Department of Public Health and Infectious Diseases, Sapienza University, Viale del Policlinico 155, Rome 00185, Italy.
  • d'Ettorre G; Department of Public Health and Infectious Diseases, Sapienza University, Viale del Policlinico 155, Rome 00185, Italy.
  • Turriziani O; Laboratory of Virology, Department of Molecular Medicine, Sapienza University, Affiliated to Istituto Pasteur Italia, Rome 00185, Italy.
  • Antonelli G; Laboratory of Virology, Department of Molecular Medicine, Sapienza University, Affiliated to Istituto Pasteur Italia, Rome 00185, Italy; Microbiology and Virology Unit, Hospital "Policlinico Umberto I", Sapienza University, Rome 00185, Italy.
Virus Res ; 295: 198283, 2021 04 02.
Article in English | MEDLINE | ID: covidwho-1009920
ABSTRACT
The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Heterogeneous patterns of IFN-I/III response in the respiratory tract of COVID-19 patients may be associated to COVID-19 severity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oropharynx / Interferon Type I / Interferons / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Virus Res Journal subject: Virology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oropharynx / Interferon Type I / Interferons / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Virus Res Journal subject: Virology Year: 2021 Document Type: Article