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Risk of COVID-19 in health-care workers in Denmark: an observational cohort study.
Iversen, Kasper; Bundgaard, Henning; Hasselbalch, Rasmus B; Kristensen, Jonas H; Nielsen, Pernille B; Pries-Heje, Mia; Knudsen, Andreas D; Christensen, Casper E; Fogh, Kamille; Norsk, Jakob B; Andersen, Ove; Fischer, Thea K; Jensen, Claus Antonio Juul; Larsen, Margit; Torp-Pedersen, Christian; Rungby, Jørgen; Ditlev, Sisse B; Hageman, Ida; Møgelvang, Rasmus; Hother, Christoffer E; Gybel-Brask, Mikkel; Sørensen, Erik; Harritshøj, Lene; Folke, Fredrik; Sten, Curt; Benfield, Thomas; Nielsen, Susanne Dam; Ullum, Henrik.
  • Iversen K; Department of Cardiology, Herlev og Gentofte Hospital, University of Copenhagen, Herlev, Denmark; Department of Emergency Medicine, Herlev og Gentofte Hospital, University of Copenhagen, Herlev, Denmark. Electronic address: kasper.karmark.iversen@regionh.dk.
  • Bundgaard H; Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Hasselbalch RB; Department of Cardiology, Herlev og Gentofte Hospital, University of Copenhagen, Herlev, Denmark; Department of Emergency Medicine, Herlev og Gentofte Hospital, University of Copenhagen, Herlev, Denmark.
  • Kristensen JH; Department of Cardiology, Herlev og Gentofte Hospital, University of Copenhagen, Herlev, Denmark; Department of Emergency Medicine, Herlev og Gentofte Hospital, University of Copenhagen, Herlev, Denmark.
  • Nielsen PB; Department of Cardiology, Herlev og Gentofte Hospital, University of Copenhagen, Herlev, Denmark; Department of Emergency Medicine, Herlev og Gentofte Hospital, University of Copenhagen, Herlev, Denmark.
  • Pries-Heje M; Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Knudsen AD; Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Department of Infectious Disease, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Christensen CE; Department of Neurology, Rigshospitalet Glostrup, University of Copenhagen, Glostrup, Denmark.
  • Fogh K; Department of Cardiology, Herlev og Gentofte Hospital, University of Copenhagen, Herlev, Denmark; Department of Emergency Medicine, Herlev og Gentofte Hospital, University of Copenhagen, Herlev, Denmark.
  • Norsk JB; Department of Cardiology, Herlev og Gentofte Hospital, University of Copenhagen, Herlev, Denmark; Department of Emergency Medicine, Herlev og Gentofte Hospital, University of Copenhagen, Herlev, Denmark.
  • Andersen O; Department of Emergency and Clinical Research Centre, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.
  • Fischer TK; Department of Clinical Research, Nordsjællands Hospital, Hillerød, Denmark.
  • Jensen CAJ; Department of Clinical Biochemistry, Nordsjællands Hospital, Hillerød, Denmark.
  • Larsen M; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
  • Torp-Pedersen C; Department of Clinical Research, Nordsjællands Hospital, Hillerød, Denmark.
  • Rungby J; Department of Endocrinology and Copenhagen Center for Translational Research, Bispebjerg Hospital, Copenhagen, Denmark.
  • Ditlev SB; Department of Pulmonary Medicine and Copenhagen Center for Translational Research, Bispebjerg Hospital, Copenhagen, Denmark.
  • Hageman I; Mental Health Services-The Capital Region of Denmark, Copenhagen, Denmark.
  • Møgelvang R; Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Hother CE; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
  • Gybel-Brask M; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
  • Sørensen E; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
  • Harritshøj L; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
  • Folke F; Emergency Medical Services, Ballerup, Copenhagen, Denmark.
  • Sten C; Diagnostisk Enhed, Bornholms Hospital, Rønne, Denmark.
  • Benfield T; Department of Infectious Disease, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.
  • Nielsen SD; Department of Infectious Disease, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Ullum H; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
Lancet Infect Dis ; 20(12): 1401-1408, 2020 12.
Article in English | MEDLINE | ID: covidwho-1009965
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Health Personnel
Subject
COVID-19
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PROCESS_OF
Object
Health Personnel
2. Symptoms PROCESS_OF Health Personnel
Subject
Symptoms
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PROCESS_OF
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Health Personnel
3. 2019 novel coronavirus PROCESS_OF Health Personnel
Subject
2019 novel coronavirus
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PROCESS_OF
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Health Personnel
4. Hospitals LOCATION_OF Seroprevalence
Subject
Hospitals
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LOCATION_OF
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Seroprevalence
5. Symptoms PROCESS_OF Participant
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Symptoms
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PROCESS_OF
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Participant
6. Antibodies PART_OF Health Personnel
Subject
Antibodies
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PART_OF
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Health Personnel
7. 2019 novel coronavirus PROCESS_OF Blood donor
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2019 novel coronavirus
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PROCESS_OF
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Blood donor
8. Infected PROCESS_OF Patients
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Infected
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Patients
9. Severe Acute Respiratory Syndrome PROCESS_OF Health Personnel
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Severe Acute Respiratory Syndrome
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PROCESS_OF
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Health Personnel
10. COVID-19 CAUSES Symptoms
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COVID-19
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CAUSES
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Symptoms
11. COVID-19 PROCESS_OF Health Personnel
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COVID-19
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PROCESS_OF
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Health Personnel
12. Symptoms PROCESS_OF Health Personnel
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Symptoms
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PROCESS_OF
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Health Personnel
13. 2019 novel coronavirus PROCESS_OF Health Personnel
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2019 novel coronavirus
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PROCESS_OF
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Health Personnel
14. Hospitals LOCATION_OF Seroprevalence
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Hospitals
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LOCATION_OF
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Seroprevalence
15. Symptoms PROCESS_OF Participant
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Symptoms
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PROCESS_OF
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Participant
16. Antibodies PART_OF Health Personnel
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Antibodies
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PART_OF
Object
Health Personnel
17. 2019 novel coronavirus PROCESS_OF Blood donor
Subject
2019 novel coronavirus
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PROCESS_OF
Object
Blood donor
18. Infected PROCESS_OF Patients
Subject
Infected
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PROCESS_OF
Object
Patients
19. Severe Acute Respiratory Syndrome PROCESS_OF Health Personnel
Subject
Severe Acute Respiratory Syndrome
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PROCESS_OF
Object
Health Personnel
20. COVID-19 CAUSES Symptoms
Subject
COVID-19
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CAUSES
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Symptoms
ABSTRACT

BACKGROUND:

Health-care workers are thought to be highly exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed to investigate the prevalence of antibodies against SARS-CoV-2 in health-care workers and the proportion of seroconverted health-care workers with previous symptoms of COVID-19.

METHODS:

In this observational cohort study, screening was offered to health-care workers in the Capital Region of Denmark, including medical, nursing, and other students who were associated with hospitals in the region. Screening included point-of-care tests for IgM and IgG antibodies against SARS-CoV-2. Test results and participant characteristics were recorded. Results were compared with findings in blood donors in the Capital Region in the study period.

FINDINGS:

Between April 15 and April 23, 2020, we screened 29 295 health-care workers, of whom 28 792 (98·28%) provided their test results. We identified 1163 (4·04% [95% CI 3·82-4·27]) seropositive health-care workers. Seroprevalence was higher in health-care workers than in blood donors (142 [3·04%] of 4672; risk ratio [RR] 1·33 [95% CI 1·12-1·58]; p<0·001). Seroprevalence was higher in male health-care workers (331 [5·45%] of 6077) than in female health-care workers (832 [3·66%] of 22 715; RR 1·49 [1·31-1·68]; p<0·001). Frontline health-care workers working in hospitals had a significantly higher seroprevalence (779 [4·55%] of 16 356) than health-care workers in other settings (384 [3·29%] of 11 657; RR 1·38 [1·22-1·56]; p<0·001). Health-care workers working on dedicated COVID-19 wards (95 [7·19%] of 1321) had a significantly higher seroprevalence than other frontline health-care workers working in hospitals (696 [4·35%] of 15 983; RR 1·65 [1·34-2·03]; p<0·001). 622 [53·5%] of 1163 seropositive participants reported symptoms attributable to SARS-CoV-2. Loss of taste or smell was the symptom that was most strongly associated with seropositivity (377 [32·39%] of 1164 participants with this symptom were seropositive vs 786 [2·84%] of 27 628 without this symptom; RR 11·38 [10·22-12·68]). The study is registered at ClinicalTrials.gov, NCT04346186.

INTERPRETATION:

The prevalence of health-care workers with antibodies against SARS-CoV-2 was low but higher than in blood donors. The risk of SARS-CoV-2 infection in health-care workers was related to exposure to infected patients. More than half of seropositive health-care workers reported symptoms attributable to COVID-19.

FUNDING:

Lundbeck Foundation.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Occupational Health / Health Personnel / COVID-19 Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Lancet Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: Occupational Health / Health Personnel / COVID-19 Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Lancet Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article