G6PD deficiency, redox homeostasis, and viral infections: implications for SARS-CoV-2 (COVID-19).
Free Radic Res
; 55(4): 364-374, 2021 Apr.
Article
in English
| MEDLINE | ID: covidwho-1010202
ABSTRACT
The COVID-19 pandemic has so far affected more than 45 million people and has caused over 1 million deaths worldwide. Infection with SARS-CoV-2, the pathogenic agent, which is associated with an imbalanced redox status, causes hyperinflammation and a cytokine storm, leading to cell death. Glucose-6-phosphate dehydrogenase (G6PD) deficient individuals may experience a hemolytic crisis after being exposed to oxidants or infection. Individuals with G6PD deficiency are more susceptible to coronavirus infection than individuals with normally functioning G6PD. An altered immune response to viral infections is found in individuals with G6PD deficiency. Evidence indicates that G6PD deficiency is a predisposing factor of COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Virus Diseases
/
SARS-CoV-2
/
COVID-19
/
Glucosephosphate Dehydrogenase Deficiency
Type of study:
Etiology study
/
Observational study
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Free Radic Res
Journal subject:
Biochemistry
Year:
2021
Document Type:
Article
Affiliation country:
10715762.2020.1866757
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