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In vitro selection of an RNA aptamer yields an interleukin-6/interleukin-6 receptor interaction inhibitor.
Ando, Takehiro; Yamamoto, Mizuki; Takamori, Yukio; Tsukamoto, Keita; Fuji, Daisuke; Kawakami, Takashi.
  • Ando T; Department of Life and Environmental Sciences, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Kofu, Yamanashi, Japan.
  • Yamamoto M; Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Kofu, Yamanashi, Japan.
  • Takamori Y; Department of Life and Environmental Sciences, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Kofu, Yamanashi, Japan.
  • Tsukamoto K; Department of Life and Environmental Sciences, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Kofu, Yamanashi, Japan.
  • Fuji D; Department of Biotechnology, Faculty of Life and Environmental Sciences, University of Yamanashi, Kofu, Yamanashi, Japan.
  • Kawakami T; Faculty of Life and Environmental Sciences, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, Kofu, Yamanashi, Japan.
Biosci Biotechnol Biochem ; 85(5): 1170-1174, 2021 Apr 24.
Article in English | MEDLINE | ID: covidwho-1010330
ABSTRACT
Interleukin-6 (IL-6) binds to the IL-6 receptor (IL-6R) subunit, related to autoimmune diseases and cytokine storm in COVID-19. In this study, we performed systematic evolution of ligands by exponential enrichment and identified a novel RNA aptamer. This RNA aptamer not only bound to IL-6R with a dissociation constant of 200 n m, but also inhibited the interaction of IL-6R with IL-6.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interleukin-6 / Receptors, Interleukin-6 / Aptamers, Nucleotide / Cytokine Release Syndrome / COVID-19 Drug Treatment Type of study: Systematic review/Meta Analysis Topics: Long Covid Limits: Humans Language: English Journal: Biosci Biotechnol Biochem Journal subject: Biochemistry / Biotechnology Year: 2021 Document Type: Article Affiliation country: Bbb

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interleukin-6 / Receptors, Interleukin-6 / Aptamers, Nucleotide / Cytokine Release Syndrome / COVID-19 Drug Treatment Type of study: Systematic review/Meta Analysis Topics: Long Covid Limits: Humans Language: English Journal: Biosci Biotechnol Biochem Journal subject: Biochemistry / Biotechnology Year: 2021 Document Type: Article Affiliation country: Bbb