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Clinical characteristics and viral shedding kinetics of 38 asymptomatic patients with coronavirus disease 2019: A retrospective observational study.
Li, Yanyan; Li, Kaishu; Xiong, Wei; Wang, Xinan; Liu, Chaowu; Liu, Chun; Tan, Weiping; Luo, Baowei; Zhu, Yongfeng; Wu, Yanbin; Yin, Huiming; Li, Xueqin; Li, Zunchang.
  • Li Y; Department of Respiratory Medicine, The People's Hospital of Binzhou City, Binzhou, China.
  • Li K; Department of Respiratory Medicine, The People's Hospital of Binzhou City, Binzhou, China.
  • Xiong W; Department of Respiration, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin.
  • Wang X; Medical Department,The People's Hospital of Binzhou City, Binzhou, China.
  • Liu C; Department of Respiration, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin.
  • Liu C; Department of Respirology & Critical Care Medicine, Third Xiangya Hospital, Central South University, Changsha.
  • Tan W; Pulmonary and Critical Care Medicine,First Affiliated Hospital, Sun Yat-Sen University.
  • Luo B; Pulmonary and Critical Care Medicine, ShuangFeng People's Hospital, Hunan Province.
  • Zhu Y; Department of Respiration, Changsha Central Hospital Affiliated to Nanhua University.
  • Wu Y; Pulmonary and Critical Care Medicine, First Affiliated Hospital, Guangxi Medical University.
  • Yin H; Pulmonary and Critical Care Medicine, First Affiliated Hospital, Hunan Medical College.
  • Li X; Nursing Department.
  • Li Z; Hematology Department, The People's Hospital of Binzhou City, Binzhou, China.
Medicine (Baltimore) ; 99(51): e23547, 2020 Dec 18.
Article in English | MEDLINE | ID: covidwho-1010676
ABSTRACT
ABSTRACT This study aims to investigate the clinical characteristics and viral shedding kinetics of asymptomatic patients with coronavirus disease 2019 (COVID-19).The data of 38 asymptomatic patients positive for SARS-CoV-2 nucleic acid were collected from February to March 2020 in Tuanfeng County, Huanggang, Hubei, China. The epidemiology, laboratory examination, chest imaging, viral nucleic acid test results, clinical characteristics, and viral shedding time were summarized in this retrospective study.The study included 20 family members of patients with COVID-19, 10 medical personnel participating in COVID-19 treatment or working in a fever clinic, 6 personnel from quarantine places, 1 individual with a close contact history with confirmed patients, and 1 local epidemic prevention personnel. All were positive for SARS-CoV-2 nucleic acid. The white blood cell (WBC) count, the absolute value of lymphocytes, C-reactive protein (CRP), and D-dimer were normal. Pneumonia manifestations were not found in the chest computed tomography (CT) scan of 36 patients; the remaining 2 cases included a 1-year-old child and a pregnant woman, and they did not undergo chest CT. The viral shedding time was 6 days.All asymptomatic patients with COVID-19 had a history of close contact or exposure. Laboratory tests were normal. Chest imaging did not show any pneumonia manifestation. The viral shedding time was <10 days, which is shorter than that of patients with COVID-19. A timely discovery of such asymptomatic infections is crucial for blocking the spread of the virus and strengthening the prevention and control measures.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Shedding / Asymptomatic Infections / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Topics: Traditional medicine Limits: Adolescent / Adult / Child / Female / Humans / Infant / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Medicine (Baltimore) Year: 2020 Document Type: Article Affiliation country: MD.0000000000023547

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Shedding / Asymptomatic Infections / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Topics: Traditional medicine Limits: Adolescent / Adult / Child / Female / Humans / Infant / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Medicine (Baltimore) Year: 2020 Document Type: Article Affiliation country: MD.0000000000023547