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Cytokine-induced liver injury in coronavirus disease-2019 (COVID-19): untangling the knots.
Anirvan, Prajna; Narain, Sonali; Hajizadeh, Negin; Aloor, Fuad Z; Singh, Shivaram P; Satapathy, Sanjaya K.
  • Anirvan P; Department of Gastroenterology, S.C.B. Medical College, Cuttack, India.
  • Narain S; Department of Medicine, Division of Rheumatology, Northwell Health, Manhasset.
  • Hajizadeh N; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead.
  • Aloor FZ; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead.
  • Singh SP; Department of Information Services, Institute of Health, Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, New Hyde Park.
  • Satapathy SK; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Northwell Health, Manhasset, New York, USA.
Eur J Gastroenterol Hepatol ; 33(1S Suppl 1): e42-e49, 2021 12 01.
Article in English | MEDLINE | ID: covidwho-1010682
ABSTRACT
Liver dysfunction manifesting as elevated aminotransferase levels has been a common feature of coronavirus disease-2019 (COVID-19) infection. The mechanism of liver injury in COVID-19 infection is unclear. However, it has been hypothesized to be a result of direct cytopathic effects of the virus, immune dysfunction and cytokine storm-related multiorgan damage, hypoxia-reperfusion injury and idiosyncratic drug-induced liver injury due to medications used in the management of COVID-19. The favored hypothesis regarding the pathophysiology of liver injury in the setting of COVID-19 is cytokine storm, an aberrant and unabated inflammatory response leading to hyperproduction of cytokines. In the current review, we have summarized the potential pathophysiologic mechanisms of cytokine-induced liver injury based on the reported literature.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokine Release Syndrome / COVID-19 / Liver Diseases Topics: Long Covid Limits: Humans Language: English Journal: Eur J Gastroenterol Hepatol Journal subject: Gastroenterology Year: 2021 Document Type: Article Affiliation country: MEG.0000000000002034

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokine Release Syndrome / COVID-19 / Liver Diseases Topics: Long Covid Limits: Humans Language: English Journal: Eur J Gastroenterol Hepatol Journal subject: Gastroenterology Year: 2021 Document Type: Article Affiliation country: MEG.0000000000002034