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Self-protection strategies and health behaviour in patients with inflammatory rheumatic diseases during the COVID-19 pandemic: results and predictors in more than 12 000 patients with inflammatory rheumatic diseases followed in the Danish DANBIO registry.
Glintborg, Bente; Jensen, Dorte Vendelbo; Engel, Sara; Terslev, Lene; Pfeiffer Jensen, Mogens; Hendricks, Oliver; Ostergaard, Mikkel; Horskjær Rasmussen, Simon; Adelsten, Thomas; Colic, Ada; Danebod, Kamilla; Kildemand, Malene; Loft, Anne Gitte; Munk, Heidi Lausten; Pedersen, Jens Kristian; Østgård, René Drage; Møller Sørensen, Christian; Krogh, Niels Steen; Agerbo, Jette; Ziegler, Connie; Hetland, Merete.
  • Glintborg B; DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet Glostrup, Glostrup, Denmark glintborg@dadlnet.dk.
  • Jensen DV; Department of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark.
  • Engel S; DANBIO, Rigshospitalet Glostrup, Glostrup, Denmark.
  • Terslev L; Department of Rheumatology, Center for Rheumatology and Spine Diseases, Gentofte University Hospital, Hellerup, Hovedstaden, Denmark.
  • Pfeiffer Jensen M; DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet Glostrup, Glostrup, Denmark.
  • Hendricks O; Department of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark.
  • Ostergaard M; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet Glostrup, Glostrup, Denmark.
  • Horskjær Rasmussen S; Department of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark.
  • Adelsten T; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet Glostrup, Glostrup, Denmark.
  • Colic A; Danish Hospital for Rheumatic Diseases, University of Southern Denmark, Sønderborg, Syddanmark, Denmark.
  • Danebod K; Department of Regional Health Research, University of Southern Denmark, Odense, Syddanmark, Denmark.
  • Kildemand M; DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet Glostrup, Glostrup, Denmark.
  • Loft AG; Department of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark.
  • Munk HL; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet Glostrup, Glostrup, Denmark.
  • Pedersen JK; Department of Rheumatology, Sjællands Universitetshospital Køge, Koge, Sjælland, Denmark.
  • Østgård RD; Department of Rheumatology, Sjællands Universitetshospital Køge, Koge, Sjælland, Denmark.
  • Møller Sørensen C; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet Glostrup, Glostrup, Denmark.
  • Krogh NS; Department of Rheumatology, Odense University Hospital, Odense, Denmark.
  • Agerbo J; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.
  • Ziegler C; Department of Clinical Medicine, Aarhus University, Aarhus, Midtjylland, Denmark.
  • Hetland M; Department of Rheumatology, Odense University Hospital, Odense, Denmark.
RMD Open ; 7(1)2021 01.
Article in English | MEDLINE | ID: covidwho-1011014
ABSTRACT

AIMS:

In Danish patients with inflammatory rheumatic diseases to explore self-protection strategies and health behaviour including adherence to disease-modifying antirheumatic treatment (DMARD) during the initial phase of the COVID-19 pandemic and again after the reopening of the society started. Furthermore, to identify characteristics of patients with high levels of anxiety and self-isolation.

METHODS:

Patients in routine care followed prospectively in the nationwide DANBIO registry were invited to answer an online questionnaire regarding disease activity and COVID-19 infection, behaviour in March and June 2020. Responses were linked to patient data in DANBIO. Characteristics potentially associated with anxiety, self-isolation and medication adherence (gender/age/diagnosis/education/work status/comorbidity/DMARD/smoking/EQ-5D/disease activity) were explored with multivariable logistic regression analyses.

RESULTS:

We included 12 789 patients (8168 rheumatoid arthritis/2068 psoriatic arthritis/1758 axial spondyloarthritis/795 other) of whom 65% were women and 36% treated with biological DMARD. Self-reported COVID-19 prevalence was 0.3%. Patients reported that they were worried to get COVID-19 infection (March/June 70%/45%) and self-isolated more than others of the same age (48%/38%). The fraction of patients who changed medication due to fear of COVID-19 were 4.1%/0.6%. Female gender, comorbidities, not working, lower education, biological treatment and poor European Quality of life, 5 dimensions were associated with both anxiety and self-isolation.

CONCLUSION:

In >12 000 patients with inflammatory arthritis, we found widespread anxiety and self-isolation, but high medication adherence, in the initial phase of the COVID-19 pandemic. This persisted during the gradual opening of society during the following months. Attention to patients' anxiety and self-isolation is important during this and potential future epidemics.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Health Behavior / Rheumatic Diseases / Pandemics / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study / Qualitative research Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Year: 2021 Document Type: Article Affiliation country: Rmdopen-2020-001505

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Health Behavior / Rheumatic Diseases / Pandemics / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study / Qualitative research Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Year: 2021 Document Type: Article Affiliation country: Rmdopen-2020-001505