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SARS-CoV-2 B cell receptor signatures in at-risk populations.
J Clin Invest ; 131(1)2021 01 04.
Article in English | MEDLINE | ID: covidwho-1011060
Semantic information from SemMedBD (by NLM)
1. Glycoproteins PART_OF 2019 novel coronavirus
Subject
Glycoproteins
Predicate
PART_OF
Object
2019 novel coronavirus
2. DNA Sequence Rearrangement PROCESS_OF Healthy Volunteers
Subject
DNA Sequence Rearrangement
Predicate
PROCESS_OF
Object
Healthy Volunteers
3. Less often PROCESS_OF Cancer Patient
Subject
Less often
Predicate
PROCESS_OF
Object
Cancer Patient
4. Less often PROCESS_OF Old age
Subject
Less often
Predicate
PROCESS_OF
Object
Old age
5. Glycoproteins PART_OF 2019 novel coronavirus
Subject
Glycoproteins
Predicate
PART_OF
Object
2019 novel coronavirus
6. DNA Sequence Rearrangement PROCESS_OF Healthy Volunteers
Subject
DNA Sequence Rearrangement
Predicate
PROCESS_OF
Object
Healthy Volunteers
7. Less often PROCESS_OF Cancer Patient
Subject
Less often
Predicate
PROCESS_OF
Object
Cancer Patient
8. Less often PROCESS_OF Old age
Subject
Less often
Predicate
PROCESS_OF
Object
Old age
ABSTRACT
Many individuals possess B cells capable of recognizing epitopes on the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this issue of the JCI, Paschold and Simnica et al. interrogated the frequency of SARS-CoV-2-specific B cell receptor rearrangements in healthy subjects based on age and cancer status. The authors found that while SARS-CoV-2-specific antibody signatures can be identified in the repertoires of young, healthy individuals, such sequences are less frequent in elderly subjects or patients with cancer. Overall, this study sheds light on B cell repertoire restrictions that might lead to an unfavorable clinical course of coronavirus disease 2019 infection in at-risk populations.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: B-Lymphocytes / Receptors, Antigen, B-Cell / SARS-CoV-2 / COVID-19 / Antibodies, Viral / Neoplasms Type of study: Etiology study / Risk factors Limits: Aged / Female / Humans / Male Language: English Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: B-Lymphocytes / Receptors, Antigen, B-Cell / SARS-CoV-2 / COVID-19 / Antibodies, Viral / Neoplasms Type of study: Etiology study / Risk factors Limits: Aged / Female / Humans / Male Language: English Year: 2021 Document Type: Article