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Lack of Antibodies to SARS-CoV-2 among Blood Donors during COVID-19 Lockdown: A Study from Saudi Arabia.
Alandijany, Thamir A; El-Kafrawy, Sherif A; Al-Ghamdi, Abrar A; Qashqari, Fadi S; Faizo, Arwa A; Tolah, Ahmed M; Hassan, Ahmed M; Sohrab, Sayed S; Hindawi, Salwa I; Badawi, Maha A; Azhar, Esam I.
  • Alandijany TA; Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 128442, Jeddah 21362, Saudi Arabia.
  • El-Kafrawy SA; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, P.O. Box 80324, Jeddah 21589, Saudi Arabia.
  • Al-Ghamdi AA; Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 128442, Jeddah 21362, Saudi Arabia.
  • Qashqari FS; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, P.O. Box 80324, Jeddah 21589, Saudi Arabia.
  • Faizo AA; Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 128442, Jeddah 21362, Saudi Arabia.
  • Tolah AM; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, P.O. Box 80324, Jeddah 21589, Saudi Arabia.
  • Hassan AM; Department of Microbiology, Faculty of Medicine, Umm Al-Qura University, P.O. Box 715, Makkah 21955, Saudi Arabia.
  • Sohrab SS; Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 128442, Jeddah 21362, Saudi Arabia.
  • Hindawi SI; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, P.O. Box 80324, Jeddah 21589, Saudi Arabia.
  • Badawi MA; Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 128442, Jeddah 21362, Saudi Arabia.
  • Azhar EI; Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 128442, Jeddah 21362, Saudi Arabia.
Healthcare (Basel) ; 9(1)2021 Jan 05.
Article in English | MEDLINE | ID: covidwho-1011456
Semantic information from SemMedBD (by NLM)
1. 2019 novel coronavirus PROCESS_OF Blood donor
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Blood donor
2. Serology (antibodies and most antigens except blood bank and infectious agents) DIAGNOSES Negative
Subject
Serology (antibodies and most antigens except blood bank and infectious agents)
Predicate
DIAGNOSES
Object
Negative
3. 2019 novel coronavirus PROCESS_OF Blood donor
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Blood donor
4. Serology (antibodies and most antigens except blood bank and infectious agents) DIAGNOSES Negative
Subject
Serology (antibodies and most antigens except blood bank and infectious agents)
Predicate
DIAGNOSES
Object
Negative
ABSTRACT
In response to the coronavirus disease 2019 (COVID-19), Saudi Arabia have imposed timely restrictions to minimize the infection spread, lower the risk for vulnerable groups, and reduce the pressure on healthcare services. The effectiveness of these measures has not been assessed comprehensively and, thereby, remains uncertain. Besides monitoring the number of COVID-19 cases diagnosed by molecular assays, the seroprevalence can serve as an indicator for the incidence rate among the general population. This study aimed to evaluate seroprevalence status of all healthy blood donors who attended one of the main largest hospital located in the western region of Saudi Arabia from 1 January to 31 May 2020. The study period covered two months prior to reporting the first COVID-19 case in the country on 2 March 2020. Importantly, it covered the period when "lock-down type" measures have been enforced. Samples were subjected to in-house enzyme-linked immunosorbent assay (ELISA), chemiluminescence immunoassay (CLIA), and microneutralization (MN). The sero statuses of all samples were confirmed negative, demonstrating the lack of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among blood donors during COVID-19 lockdown period. This study supports the hypothesis that COVID-19 restrictions have potential for limiting the extent of the infection.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Randomized controlled trials Language: English Year: 2021 Document Type: Article Affiliation country: Healthcare9010051

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Randomized controlled trials Language: English Year: 2021 Document Type: Article Affiliation country: Healthcare9010051