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Cytokine storm of a different flavour: The different cytokine signature of SARS-CoV-2, the cause of COVID-19, from the original SARS outbreak.
Griffin, Daniel O; Jensen, Alexandra; Khan, Mushmoom; Chin, Jessica; Chin, Kelly; Saad, Jennifer; Parnell, Ryan; Awwad, Christopher; Patel, Darshan.
  • Griffin DO; Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA; Department of Medicine, Division of Infectious Diseases, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA. Electronic address: dgriffin@prohealthcare.com.
  • Jensen A; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
  • Khan M; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
  • Chin J; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
  • Chin K; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
  • Saad J; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
  • Parnell R; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
  • Awwad C; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
  • Patel D; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
J Glob Antimicrob Resist ; 24: 90-92, 2021 03.
Article in English | MEDLINE | ID: covidwho-1012433
ABSTRACT
Here we present a case series of three patients with COVID-19 (coronavirus disease 2019) who had a cytokine panel that revealed elevation of interleukin-6 (IL-6) but normal levels of interleukin-10 (IL-10), interferon-gamma (INF-γ) and interleukin-8 (IL-8), in contrast to the cytokine signature described in severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). We also documented evidence of a compromised T-cell IFN-γ response in two of these patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokines / Coronavirus Infections / Severe Acute Respiratory Syndrome / Cytokine Release Syndrome / COVID-19 Type of study: Case report / Observational study Limits: Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: J Glob Antimicrob Resist Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokines / Coronavirus Infections / Severe Acute Respiratory Syndrome / Cytokine Release Syndrome / COVID-19 Type of study: Case report / Observational study Limits: Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: J Glob Antimicrob Resist Year: 2021 Document Type: Article