Polycations and polyanions in SARS-CoV-2 infection.
Med Hypotheses
; 146: 110470, 2021 Jan.
Article
in English
| MEDLINE | ID: covidwho-1012486
ABSTRACT
We hypothesize that polycations, such as nuclear histones, released by neutrophils COVID-19 aggravate COVID-19 by multiple mechanisms (A) Neutralization of the electrostatic repulsion between the virus particles and the cell membrane, thereby enhancing receptor-mediated entry. (B) Binding to the virus particles, thereby inducing opsonin-mediated endocytosis. (C) Adding to the cytotoxicity, in conjunction with oxidants, cytokines and other pro-inflammatory substances secreted by cells of the innate immunity system. These effects may be alleviated by the administration of negatively charged polyanions such as heparins and heparinoids.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Polyelectrolytes
/
COVID-19
/
Models, Biological
Limits:
Humans
Language:
English
Journal:
Med Hypotheses
Year:
2021
Document Type:
Article
Affiliation country:
J.mehy.2020.110470
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