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Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults.
Libster, Romina; Pérez Marc, Gonzalo; Wappner, Diego; Coviello, Silvina; Bianchi, Alejandra; Braem, Virginia; Esteban, Ignacio; Caballero, Mauricio T; Wood, Cristian; Berrueta, Mabel; Rondan, Aníbal; Lescano, Gabriela; Cruz, Pablo; Ritou, Yvonne; Fernández Viña, Valeria; Álvarez Paggi, Damián; Esperante, Sebastián; Ferreti, Adrián; Ofman, Gastón; Ciganda, Álvaro; Rodriguez, Rocío; Lantos, Jorge; Valentini, Ricardo; Itcovici, Nicolás; Hintze, Alejandra; Oyarvide, M Laura; Etchegaray, Candela; Neira, Alejandra; Name, Ivonne; Alfonso, Julieta; López Castelo, Rocío; Caruso, Gisela; Rapelius, Sofía; Alvez, Fernando; Etchenique, Federico; Dimase, Federico; Alvarez, Darío; Aranda, Sofía S; Sánchez Yanotti, Clara; De Luca, Julián; Jares Baglivo, Sofía; Laudanno, Sofía; Nowogrodzki, Florencia; Larrea, Ramiro; Silveyra, María; Leberzstein, Gabriel; Debonis, Alejandra; Molinos, Juan; González, Miguel; Perez, Eduardo.
  • Libster R; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Pérez Marc G; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Wappner D; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Coviello S; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Bianchi A; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Braem V; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Esteban I; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Caballero MT; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Wood C; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Berrueta M; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Rondan A; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Lescano G; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Cruz P; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Ritou Y; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Fernández Viña V; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Álvarez Paggi D; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Esperante S; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Ferreti A; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Ofman G; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Ciganda Á; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Rodriguez R; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Lantos J; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Valentini R; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Itcovici N; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Hintze A; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Oyarvide ML; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Etchegaray C; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Neira A; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Name I; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Alfonso J; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • López Castelo R; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Caruso G; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Rapelius S; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Alvez F; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Etchenique F; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Dimase F; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Alvarez D; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Aranda SS; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Sánchez Yanotti C; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • De Luca J; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Jares Baglivo S; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Laudanno S; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Nowogrodzki F; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Larrea R; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Silveyra M; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
  • Leberzstein G; From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Rese
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N Engl J Med ; 384(7): 610-618, 2021 02 18.
Article in English | MEDLINE | ID: covidwho-1012716
ABSTRACT

BACKGROUND:

Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, perhaps because antibodies should be administered earlier in the course of illness.

METHODS:

We conducted a randomized, double-blind, placebo-controlled trial of convalescent plasma with high IgG titers against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in older adult patients within 72 hours after the onset of mild Covid-19 symptoms. The primary end point was severe respiratory disease, defined as a respiratory rate of 30 breaths per minute or more, an oxygen saturation of less than 93% while the patient was breathing ambient air, or both. The trial was stopped early at 76% of its projected sample size because cases of Covid-19 in the trial region decreased considerably and steady enrollment of trial patients became virtually impossible.

RESULTS:

A total of 160 patients underwent randomization. In the intention-to-treat population, severe respiratory disease developed in 13 of 80 patients (16%) who received convalescent plasma and 25 of 80 patients (31%) who received placebo (relative risk, 0.52; 95% confidence interval [CI], 0.29 to 0.94; P = 0.03), with a relative risk reduction of 48%. A modified intention-to-treat analysis that excluded 6 patients who had a primary end-point event before infusion of convalescent plasma or placebo showed a larger effect size (relative risk, 0.40; 95% CI, 0.20 to 0.81). No solicited adverse events were observed.

CONCLUSIONS:

Early administration of high-titer convalescent plasma against SARS-CoV-2 to mildly ill infected older adults reduced the progression of Covid-19. (Funded by the Bill and Melinda Gates Foundation and the Fundación INFANT Pandemic Fund; Dirección de Sangre y Medicina Transfusional del Ministerio de Salud number, PAEPCC19, Plataforma de Registro Informatizado de Investigaciones en Salud number, 1421, and ClinicalTrials.gov number, NCT04479163.).
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Insufficiency / Immunoglobulin G / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Aged / Female / Humans / Male Language: English Journal: N Engl J Med Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Insufficiency / Immunoglobulin G / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Aged / Female / Humans / Male Language: English Journal: N Engl J Med Year: 2021 Document Type: Article